Oxidative stress markers in breast cancer /Meme kanserinde oksidatif stres belirtecleri

Purpose: The aim of this study was to compare serum Total Antioxidant Status (TAS), Total Oxidant Status (TOS), Oxidative Stress Index (OSI) and Ischemia Modified Albumin (IMA) levels in breast cancer patients and healthy women and to determine whether there is a relationship between oxidative stres...

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Bibliographic Details
Published in:Pamukkale Medical Journal 2024-07, Vol.17 (3), p.402
Main Authors: Fenercioglu, Ozge, Bozkaya, Giray, Uzuncan, Nuriye, Zengel, Baha
Format: Article
Language:English
Subjects:
Albumin
Analysis
Antioxidants
Breast cancer
Cancer
Development and progression
Health aspects
Ischemia
Oncology, Experimental
Oxidative stress
Surgical clinics
Women
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Summary:Purpose: The aim of this study was to compare serum Total Antioxidant Status (TAS), Total Oxidant Status (TOS), Oxidative Stress Index (OSI) and Ischemia Modified Albumin (IMA) levels in breast cancer patients and healthy women and to determine whether there is a relationship between oxidative stress markers and breast cancer. Materials and methods: Newly diagnosed 106 breast cancer patients at the Bozyaka Training and Research Hospital General Surgery Clinic and 30 healthy women were included in the study. Serum levels of IMA, TAS, TOS were analyzed by spectrophotometric methods. Results: IMA, TOS and OSI values were found significantly higher in the breast cancer group. Although the TAS values in patients with breast cancer were lower than the control group, the difference was not statistically significant. Conclusions: In our study, it was seen that oxidative stress levels increased in breast cancer patients due to decreased TAS, and significantly increased IMA, TOS and OSI results. There was no correlation of histopathologic findings with IMA, TOS and OSI levels in terms of tumor grade and size. Disturbed oxidative stress status and IMA may contribute to the pathogenesis of breast cancer and more comprehensive studies are needed for prognostic value. Keywords: Breast cancer, biomarkers, ischemia-modified albumin, oxidative stress. Amac: Calismamizda oksidatif stres ile meme kanseri arasinda iliski olup olmadigini arastirmak icin, meme kanseri hastalarinda ve saglikli kadinlarda serumda Total Antioksidan Seviye (TAS), Total Oksidan Seviye (TOS), Oksidatif Stres Indeksi (OSI) ve Iskemi Modifiye Albumin (IMA) degerlerinin karsilastirmasi amaclandi. Gerec ve yontem: Bozyaka Egitim ve Arastirma Hastanesi Genel Cerrahi Klinigi'nde yeni tani almis ve henuz tedavi almamis 106 meme kanseri hastasi ve saglikli 30 kadin calismaya alindi. Serum TAS, TOS ve IMA duzeyleri spektrofotometrik yontemle analiz edildi. Bulgular: Meme kanseri grubunda IMA, TOS ve OSI duzeyleri, istatistiksel olarak anlamli yuksek bulundu. TAS degerleri ise, meme kanserli hastalarda kontrol grubuna gore dusuk olmasina ragmen, aradaki fark istatistiksel olarak anlamli degildi. Sonuc: Calismamizda meme kanseri hastalarinda azalmis TAS, anlamli derecede artmis IMA, TOS ve OSI sonuclari sebebiyle oksidatif stres duzeylerinin arttigi anlasilmaktadir. IMA, TOS ve OSI meme kanseri patofizyolojisinde onemli bir belirtec olup prognostik deger icin daha kapsamli calismalara ihtiyac duyulmaktadir. Ana
ISSN:1309-9833
DOI:10.31362/patd.1388561