Disease and treatment-related comorbidities in rheumatoid arthritis/Romatoid artritte hastalik ve tedavi iliskili komorbiditeler

• Published in: Journal of Turkish Society for Rheumatology 2024-07, Vol.16 (2), p.64
• Main Authors: Agbuga, Ozlem Dogan, Ersozlu, Emine Duygu
• Format: Article
• Language: English
• Subjects: Adalimumab; Arthritis; Cardiovascular diseases; Comorbidity; Denosumab; Development and progression; Health aspects; Lung diseases; Medical research; Medicine, Experimental; Mortality; Osteoporosis; Rheumatoid factor; Tofacitinib
• ISSN: 2651-2653
• DOI: 10.4274/raed.galenos.2024.74755

Rheumatoid arthritis (RA) is a chronic, progressive disease affecting systemic connective tissues, including synovial membranes in joints and extra-articular systems. The global prevalence is estimated between 0.5% and 2%, with a higher incidence observed in women, individuals with a family history, and smokers. The disease's etiology is primarily attributed to immune processes in the synovial membrane and fluid of joints. Importantly, RA is a systemic condition affecting joints, organs, and systems, including the cardiovascular, renal, pulmonary, and neuropsychiatric systems. In one study, 40% of RA patients experienced complications, with a significant incidence of 8.3% among those with cardiovascular disease, interstitial lung disease, osteoporosis, and metabolic syndrome. Sustained inflammation and immune dysregulation, hallmark features of RA, significantly contribute to the onset and progression of associated comorbidities. Comorbidities frequently coexisting with RA encompass cardiovascular diseases, pulmonary disorders, osteoporosis, malignancies, and infections. Such comorbidities exert a direct impact on patient quality of life, functional capacity, and mortality rates. The emergence of these comorbid conditions is not solely attributable to the disease itself but may also be influenced, either positively or negatively, by the therapeutic agents employed. Keywords: Rheumatoid arthritis, comorbidity, treatment Romatoid artrit (RA), eklemlerdeki sinoviyal membranlar ve eklem disi sistemler de dahil olmak uzere sistemik bag dokularini etkileyen kronik, ilerleyici bir hastaliktir. Kuresel prevalansin %0,5 ile %2 arasinda oldugu tahmin edilmektedir; kadinlarda, aile oykusu olanlarda ve sigara icenlerde daha yuksek bir insidans gozlenmektedir. Hastaligin etiyolojisi oncelikle sinovyal membrandaki ve eklem sivisindaki bagisiklik sureclerine atfedilir. RA, kardiyovaskuler, renal, pulmoner ve noropsikiyatrik sistemler de dahil olmak uzere eklemleri, organlari ve sistemleri etkileyen sistemik bir hastaliktir. Yapilmis bir calismada RA tanili hastalarin %40'inda komplikasyon gorulmus olup bunlarin arasinda kardiyovaskuler hastalik, interstisyel akciger hastaligi, osteoporoz ve metabolik sendromu gorulme insidansi %8,3 saptanmistir. RA'nin ayirt edici ozellikleri olan surekli enflamasyon ve immun duzensizlik, iliskili komorbiditelerin baslangicina ve ilerlemesine onemli olcude katkida bulunur. RA'ya siklikla eslik eden komorbiditeler kardiyovaskuler hastalik