N-butanamide

Benzazoles, such as benzoxazoles and benzothiazoles, are compounds with important biological and pharmacological activities and important intermediaries in synthesis. This report presents the synthesis of a butanamide derived from linking 5-chloro-2-aminobenzoxazole and 2-aminobenzothiazole via 4-ch...

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Bibliographic Details
Published in:MolBank 2024-09, Vol.2024 (3)
Main Authors: Pilotzi-Xahuentitla, Hugo, Canche-Naal, Gabriela del Carmen, O, Navarrete-Vázquez, Gabriel, Hernández-Núñez, Emanuel
Format: Article
Language:English
Subjects:
Amino acids
Amino compounds
Analysis
Benzene
Butane
Chemical synthesis
Hypoglycemic agents
Identification and classification
Methods
Molecules
Oxazoles
Raw materials
Structure
Thiazoles
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Summary:Benzazoles, such as benzoxazoles and benzothiazoles, are compounds with important biological and pharmacological activities and important intermediaries in synthesis. This report presents the synthesis of a butanamide derived from linking 5-chloro-2-aminobenzoxazole and 2-aminobenzothiazole via 4-chlorobutanoyl chloride. The corresponding compound N -(benzothiazol-2-yl)-4-((5-chlorobenzoxazol-2-yl)aminobutanamide was obtained at a 76% global yield using accessible starting materials and a methodology in two reaction steps. Furthermore, we conducted docking studies of this compound on 3-TOP protein to explore its potential as an antidiabetic agent.
ISSN:1422-8599
1422-8599
DOI:10.3390/M1854