Therapeutic Strategies in Advanced Cervical Cancer Detection, Prevention and Treatment

Cervical cancer is ranked the fourth most common cause of cancer related deaths amongst women. The situation is particularly dire in low to lower middle-income countries. It continues to affect these countries due to poor vaccine coverage and screening. Cervical cancer is mostly detected in the adva...

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Bibliographic Details
Published in:OncoTargets and therapy 2024-09, Vol.17, p.785
Main Authors: Sebutsoe, Xolisiwe M, Tsotetsi, Nrateng Joyful Nonhlanzeko, Jantjies, Zodwa Edith, Raphela-Choma, Po, Choene, Mpho S, Motadi, lesetja R
Format: Article
Language:English
Subjects:
Analysis
Cancer vaccines
Care and treatment
Cervical cancer
Complications and side effects
Dosage and administration
MicroRNA
Papillomavirus infections
Prevention
Risk factors
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Summary:Cervical cancer is ranked the fourth most common cause of cancer related deaths amongst women. The situation is particularly dire in low to lower middle-income countries. It continues to affect these countries due to poor vaccine coverage and screening. Cervical cancer is mostly detected in the advanced stages leading to poor outcomes. This review focuses on the progress made to date to improve early detection and targeted therapy using both circulating RNA. Vaccine has played a major role in cervical cancer control in vaccinated young woman in mainly developed countries yet in low-income countries with challenges of 3 dose vaccination affordability, cervical cancer continues to be the second most deadly amongst women. In this review, we show the progress made in reducing cervical cancer using vaccination that in combination with other treatments that might improve survival in cervical cancer. We further show with both miRNA and siRNA that targeted therapy and specific markers might be ideal for early detection of cervical cancer in low-income countries. These markers are either upregulated or down regulated in cancer providing clue to the stage of the cancer. Keywords: cervical cancer, miRNA, HPV, vaccine and siRNA
ISSN:1178-6930
1178-6930
DOI:10.2147/OTT.S482781