EXPOSURE TO ARSENIC IN DRINKING WATER AND RISK OF BLADDER CANCER/IZLOZENOST ARSENU U VODI ZA PICE I RIZIK OD RAKA MOKRACNOG MJEHURA

The municipality of Bogatic, part of Macva District, belongs to the Pannonian Basin, where high concentrations of arsenic in artesian wells were detected. Numerous epidemiological studies have confirmed the association of exposure to arsenic in drinking water and bladder cancer (C67). This retrospec...

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Bibliographic Details
Published in:Acta clinica Croatica (Tisak) 2024-03, Vol.63 (1), p.55
Main Authors: Sreckovic, Marijana, Backovic, Dusan, Dragicevic, Igor, Nikolic, Ljubica Pajic, Mulic, Maida, Damnjanovic, Bojan
Format: Article
Language:English
Subjects:
Arsenic
Artesian wells
Bladder cancer
Cancer
Contamination
Diagnosis
Drinking water
Environmental aspects
Epidemiology
Health aspects
Oncology, Experimental
Public health
Risk factors
Type 2 diabetes
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Summary:The municipality of Bogatic, part of Macva District, belongs to the Pannonian Basin, where high concentrations of arsenic in artesian wells were detected. Numerous epidemiological studies have confirmed the association of exposure to arsenic in drinking water and bladder cancer (C67). This retrospective ten-year analysis included age-standardized incidence rates (ASRs) and age-specific incidence rates of C67 in the municipality of Bogatic and rural municipalities of Macva District. The concentration of arsenic in drinking water was determined at Sabac Public Health Institute (PHI) laboratories in 2015. ASRs were estimated using data from regional cancer registries at Sabac PHI and compared by use of the Mann-Whitney U test. Control population was recruited from an area where there were no artesian wells or hydrogeological conditions that would indicate elevated concentrations of arsenic in drinking water. Arsenic levels in all artesian wells in Bogatic municipality were 1.4 to 41 times higher than the maximum permissible concentration (mean 120 [micro]g/L[+ or -]165). Female subjects from Bogatic municipality had higher ASRs of C67 compared with the populations in rural municipalities of Macva District (p0.05). Our analyses suggested that exposure to arsenic in drinking water could triple the risk of bladder cancer. These results support the conclusions of previous studies that there may be an association between higher concentrations of arsenic in drinking water and higher ASRs of bladder cancer in both male and female subjects. Key words: Macva District; Arsenic; Bladder cancer; Artesian wells; Ten-year analysis Opcina Bogatic, dio Macvanskog okruga, pripada Panonskom bazenu gdje su otkrivene visoke koncentracije arsena u arteskim bunarima. Brojne epidemioloske studije su potvrdile povezanost izlozenosti arsenu u vodi za pice i raka mokracnog mjehura (C67). Ova retrospektivna desetogodisnja analiza obuhvatila je standardizirane stope incidencije (ASRs) i za dob specificne stope incidencije C67 u opcini Bogatic i ruralnim opcinama Macvanskog okruga. Koncentracija arsena u vodi za pice odredena je u laboratoriju Zavoda za javno zdravlje Sabac (ZZJZ) 2015. godine. ASRs su procijenjene koristen
ISSN:0353-9466
DOI:10.20471/acc.2024.63.01.7