Utility of Hematological and Biochemical Parameters as a Screening Tool for Assessing Coronavirus Disease 2019 Infection and its Severity

Background: The rapidly evolving pandemic of Coronavirus disease 2019 (COVID-19) has presented with clinical severity, which varies from asymptomatic cases to being fatal in others. The need of the hour is to find meaningful and cost-effective COVID-19 biomarkers out of conventional hematological an...

Full description

Saved in:
Bibliographic Details
Published in:The journal of microscopy & ultrastructure 2024-10, Vol.12 (4), p.214-220
Main Authors: Alam, Sana, Khan, Sabina, Jain, Vineet, Kashyap, Varun, Kapur, Prem
Format: Article
Language:English
Subjects:
China
Coronaviruses
Diagnosis
Diseases
Epidemics
Health aspects
India
Lymphocytes
Medical research
Medical screening
Medical tests
Medicine, Experimental
Prognosis
Urea
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites cdi_FETCH-LOGICAL-c1071-9075895bbbe1163fd36b7e617c6c45c9be106ae751aedb686707bc85655bc00c3
container_end_page 220
container_issue 4
container_start_page 214
container_title The journal of microscopy & ultrastructure
container_volume 12
creator Alam, Sana
Khan, Sabina
Jain, Vineet
Kashyap, Varun
Kapur, Prem
description Background: The rapidly evolving pandemic of Coronavirus disease 2019 (COVID-19) has presented with clinical severity, which varies from asymptomatic cases to being fatal in others. The need of the hour is to find meaningful and cost-effective COVID-19 biomarkers out of conventional hematological and biochemical parameters, which will help in the early identification of patients with a poor prognosis, leading to timely intervention. Aim: The aim was to analyze different biochemical and hematological parameters in COVID-19 patients and also to study the association of these parameters with disease severity. Materials and Methods: Cross-sectional observational study was carried out on 100 COVID-19 patients from a hospital from July to October 2020. Based on saturation of oxygen (SpO[sub.2]), admitted patients were grouped into mild-moderate (SpO[sub.2] ≥90) and severe groups (SpO[sub.2]
doi_str_mv 10.4103/jmau.jmau_59_22
format article
fullrecord <record><control><sourceid>gale_cross</sourceid><recordid>TN_cdi_gale_infotracmisc_A820670061</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A820670061</galeid><sourcerecordid>A820670061</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1071-9075895bbbe1163fd36b7e617c6c45c9be106ae751aedb686707bc85655bc00c3</originalsourceid><addsrcrecordid>eNptUU1rAjEQDaWFivXca6BnNdk1ye7R2g8FoQUVegvZ7MRGdpOSrII_of-6u9pSCmWG-Xi8GYZ5CN1SMppQko53tdqPuiBZLpPkAvWShKbDLCPp5U8t8rdrNIhxRwihWcL5hPbQ56axlW2O2Bs8h1o1vvJbq1WFlSvxvfX6HepT_6qCqqGBELFqHa90AHDWbfHa-wobH_A0Roixg2Y-eKcONuwjfrARVAScEJrjhTOgG-vdab9tIl7BAUJ7wQ26MqqKMPjOfbR5elzP5sPly_NiNl0ONSWCDnMiWJazoiiAUp6aMuWFAE6F5nrCdN7ChCsQjCooC55xQUShM8YZKzQhOu2ju_PerapAWmd8E5SubdRymiWk5RNOW9boH1ZrZfcO78DYFv8zMD4P6OBjDGDkR7C1CkdJiew0kid5fjVKvwCekYdU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Utility of Hematological and Biochemical Parameters as a Screening Tool for Assessing Coronavirus Disease 2019 Infection and its Severity</title><source>PubMed Central</source><creator>Alam, Sana ; Khan, Sabina ; Jain, Vineet ; Kashyap, Varun ; Kapur, Prem</creator><creatorcontrib>Alam, Sana ; Khan, Sabina ; Jain, Vineet ; Kashyap, Varun ; Kapur, Prem</creatorcontrib><description>Background: The rapidly evolving pandemic of Coronavirus disease 2019 (COVID-19) has presented with clinical severity, which varies from asymptomatic cases to being fatal in others. The need of the hour is to find meaningful and cost-effective COVID-19 biomarkers out of conventional hematological and biochemical parameters, which will help in the early identification of patients with a poor prognosis, leading to timely intervention. Aim: The aim was to analyze different biochemical and hematological parameters in COVID-19 patients and also to study the association of these parameters with disease severity. Materials and Methods: Cross-sectional observational study was carried out on 100 COVID-19 patients from a hospital from July to October 2020. Based on saturation of oxygen (SpO[sub.2]), admitted patients were grouped into mild-moderate (SpO[sub.2] ≥90) and severe groups (SpO[sub.2] &lt;90). Hematological and biochemical parameters were studied in both groups, and association with disease severity was analyzed. Results: Out of 100 patients, 57 patients were seen in the mild-moderate group (SpO[sub.2] ≥90), while 43 patients (SpO[sub.2] &lt;90) belonged to the severe category. Males were predominant in both mild-moderate and severe groups. Among the hematological parameters, statistically significant higher values of absolute neutrophil count (P = 0.046) and significantly lower absolute lymphocyte count (P = 0.003) values were observed. With regard to biochemical parameters, increased urea and decreased total protein were found in the severe category and this association was statistically significant. Conclusion: To conclude, early identification and monitoring of hematological and biochemical parameters, especially those associated with higher disease severity, may contribute toward improving disease outcomes. Keywords: Coronavirus disease 2019, disease severity, laboratory parameters</description><identifier>ISSN: 2213-879X</identifier><identifier>EISSN: 2213-8803</identifier><identifier>DOI: 10.4103/jmau.jmau_59_22</identifier><language>eng</language><publisher>Medknow Publications and Media Pvt. Ltd</publisher><subject>China ; Coronaviruses ; Diagnosis ; Diseases ; Epidemics ; Health aspects ; India ; Lymphocytes ; Medical research ; Medical screening ; Medical tests ; Medicine, Experimental ; Prognosis ; Urea</subject><ispartof>The journal of microscopy &amp; ultrastructure, 2024-10, Vol.12 (4), p.214-220</ispartof><rights>COPYRIGHT 2024 Medknow Publications and Media Pvt. Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c1071-9075895bbbe1163fd36b7e617c6c45c9be106ae751aedb686707bc85655bc00c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Alam, Sana</creatorcontrib><creatorcontrib>Khan, Sabina</creatorcontrib><creatorcontrib>Jain, Vineet</creatorcontrib><creatorcontrib>Kashyap, Varun</creatorcontrib><creatorcontrib>Kapur, Prem</creatorcontrib><title>Utility of Hematological and Biochemical Parameters as a Screening Tool for Assessing Coronavirus Disease 2019 Infection and its Severity</title><title>The journal of microscopy &amp; ultrastructure</title><description>Background: The rapidly evolving pandemic of Coronavirus disease 2019 (COVID-19) has presented with clinical severity, which varies from asymptomatic cases to being fatal in others. The need of the hour is to find meaningful and cost-effective COVID-19 biomarkers out of conventional hematological and biochemical parameters, which will help in the early identification of patients with a poor prognosis, leading to timely intervention. Aim: The aim was to analyze different biochemical and hematological parameters in COVID-19 patients and also to study the association of these parameters with disease severity. Materials and Methods: Cross-sectional observational study was carried out on 100 COVID-19 patients from a hospital from July to October 2020. Based on saturation of oxygen (SpO[sub.2]), admitted patients were grouped into mild-moderate (SpO[sub.2] ≥90) and severe groups (SpO[sub.2] &lt;90). Hematological and biochemical parameters were studied in both groups, and association with disease severity was analyzed. Results: Out of 100 patients, 57 patients were seen in the mild-moderate group (SpO[sub.2] ≥90), while 43 patients (SpO[sub.2] &lt;90) belonged to the severe category. Males were predominant in both mild-moderate and severe groups. Among the hematological parameters, statistically significant higher values of absolute neutrophil count (P = 0.046) and significantly lower absolute lymphocyte count (P = 0.003) values were observed. With regard to biochemical parameters, increased urea and decreased total protein were found in the severe category and this association was statistically significant. Conclusion: To conclude, early identification and monitoring of hematological and biochemical parameters, especially those associated with higher disease severity, may contribute toward improving disease outcomes. Keywords: Coronavirus disease 2019, disease severity, laboratory parameters</description><subject>China</subject><subject>Coronaviruses</subject><subject>Diagnosis</subject><subject>Diseases</subject><subject>Epidemics</subject><subject>Health aspects</subject><subject>India</subject><subject>Lymphocytes</subject><subject>Medical research</subject><subject>Medical screening</subject><subject>Medical tests</subject><subject>Medicine, Experimental</subject><subject>Prognosis</subject><subject>Urea</subject><issn>2213-879X</issn><issn>2213-8803</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNptUU1rAjEQDaWFivXca6BnNdk1ye7R2g8FoQUVegvZ7MRGdpOSrII_of-6u9pSCmWG-Xi8GYZ5CN1SMppQko53tdqPuiBZLpPkAvWShKbDLCPp5U8t8rdrNIhxRwihWcL5hPbQ56axlW2O2Bs8h1o1vvJbq1WFlSvxvfX6HepT_6qCqqGBELFqHa90AHDWbfHa-wobH_A0Roixg2Y-eKcONuwjfrARVAScEJrjhTOgG-vdab9tIl7BAUJ7wQ26MqqKMPjOfbR5elzP5sPly_NiNl0ONSWCDnMiWJazoiiAUp6aMuWFAE6F5nrCdN7ChCsQjCooC55xQUShM8YZKzQhOu2ju_PerapAWmd8E5SubdRymiWk5RNOW9boH1ZrZfcO78DYFv8zMD4P6OBjDGDkR7C1CkdJiew0kid5fjVKvwCekYdU</recordid><startdate>20241001</startdate><enddate>20241001</enddate><creator>Alam, Sana</creator><creator>Khan, Sabina</creator><creator>Jain, Vineet</creator><creator>Kashyap, Varun</creator><creator>Kapur, Prem</creator><general>Medknow Publications and Media Pvt. Ltd</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20241001</creationdate><title>Utility of Hematological and Biochemical Parameters as a Screening Tool for Assessing Coronavirus Disease 2019 Infection and its Severity</title><author>Alam, Sana ; Khan, Sabina ; Jain, Vineet ; Kashyap, Varun ; Kapur, Prem</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1071-9075895bbbe1163fd36b7e617c6c45c9be106ae751aedb686707bc85655bc00c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>China</topic><topic>Coronaviruses</topic><topic>Diagnosis</topic><topic>Diseases</topic><topic>Epidemics</topic><topic>Health aspects</topic><topic>India</topic><topic>Lymphocytes</topic><topic>Medical research</topic><topic>Medical screening</topic><topic>Medical tests</topic><topic>Medicine, Experimental</topic><topic>Prognosis</topic><topic>Urea</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alam, Sana</creatorcontrib><creatorcontrib>Khan, Sabina</creatorcontrib><creatorcontrib>Jain, Vineet</creatorcontrib><creatorcontrib>Kashyap, Varun</creatorcontrib><creatorcontrib>Kapur, Prem</creatorcontrib><collection>CrossRef</collection><jtitle>The journal of microscopy &amp; ultrastructure</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alam, Sana</au><au>Khan, Sabina</au><au>Jain, Vineet</au><au>Kashyap, Varun</au><au>Kapur, Prem</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Utility of Hematological and Biochemical Parameters as a Screening Tool for Assessing Coronavirus Disease 2019 Infection and its Severity</atitle><jtitle>The journal of microscopy &amp; ultrastructure</jtitle><date>2024-10-01</date><risdate>2024</risdate><volume>12</volume><issue>4</issue><spage>214</spage><epage>220</epage><pages>214-220</pages><issn>2213-879X</issn><eissn>2213-8803</eissn><abstract>Background: The rapidly evolving pandemic of Coronavirus disease 2019 (COVID-19) has presented with clinical severity, which varies from asymptomatic cases to being fatal in others. The need of the hour is to find meaningful and cost-effective COVID-19 biomarkers out of conventional hematological and biochemical parameters, which will help in the early identification of patients with a poor prognosis, leading to timely intervention. Aim: The aim was to analyze different biochemical and hematological parameters in COVID-19 patients and also to study the association of these parameters with disease severity. Materials and Methods: Cross-sectional observational study was carried out on 100 COVID-19 patients from a hospital from July to October 2020. Based on saturation of oxygen (SpO[sub.2]), admitted patients were grouped into mild-moderate (SpO[sub.2] ≥90) and severe groups (SpO[sub.2] &lt;90). Hematological and biochemical parameters were studied in both groups, and association with disease severity was analyzed. Results: Out of 100 patients, 57 patients were seen in the mild-moderate group (SpO[sub.2] ≥90), while 43 patients (SpO[sub.2] &lt;90) belonged to the severe category. Males were predominant in both mild-moderate and severe groups. Among the hematological parameters, statistically significant higher values of absolute neutrophil count (P = 0.046) and significantly lower absolute lymphocyte count (P = 0.003) values were observed. With regard to biochemical parameters, increased urea and decreased total protein were found in the severe category and this association was statistically significant. Conclusion: To conclude, early identification and monitoring of hematological and biochemical parameters, especially those associated with higher disease severity, may contribute toward improving disease outcomes. Keywords: Coronavirus disease 2019, disease severity, laboratory parameters</abstract><pub>Medknow Publications and Media Pvt. Ltd</pub><doi>10.4103/jmau.jmau_59_22</doi><tpages>7</tpages></addata></record>
fulltext fulltext
identifier ISSN: 2213-879X
ispartof The journal of microscopy & ultrastructure, 2024-10, Vol.12 (4), p.214-220
issn 2213-879X
2213-8803
language eng
recordid cdi_gale_infotracmisc_A820670061
source PubMed Central
subjects China
Coronaviruses
Diagnosis
Diseases
Epidemics
Health aspects
India
Lymphocytes
Medical research
Medical screening
Medical tests
Medicine, Experimental
Prognosis
Urea
title Utility of Hematological and Biochemical Parameters as a Screening Tool for Assessing Coronavirus Disease 2019 Infection and its Severity
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T15%3A21%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Utility%20of%20Hematological%20and%20Biochemical%20Parameters%20as%20a%20Screening%20Tool%20for%20Assessing%20Coronavirus%20Disease%202019%20Infection%20and%20its%20Severity&rft.jtitle=The%20journal%20of%20microscopy%20&%20ultrastructure&rft.au=Alam,%20Sana&rft.date=2024-10-01&rft.volume=12&rft.issue=4&rft.spage=214&rft.epage=220&rft.pages=214-220&rft.issn=2213-879X&rft.eissn=2213-8803&rft_id=info:doi/10.4103/jmau.jmau_59_22&rft_dat=%3Cgale_cross%3EA820670061%3C/gale_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c1071-9075895bbbe1163fd36b7e617c6c45c9be106ae751aedb686707bc85655bc00c3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/&rft_galeid=A820670061&rfr_iscdi=true