Evaluation of serum ferritin and its correlation with biomarkers of early onset neonatal sepsis

Background A clinical illness known as neonatal sepsis is defined by disseminated infection symptoms and bacteremia during the first 30 days of life. It is categorized as early-onset neonatal sepsis and late-onset neonatal sepsis It is one of the leading causes of mortality and morbidity worldwide....

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Published in:The Egyptian journal of haematology : the official journal of the Egyptian Society of Haematology 2024-10, Vol.49 (4), p.438-443
Main Authors: Abdou, Rania M, Hamza, Mohamed T. M, Iskander, Sandra M, Hussein, Mohamed H. M
Format: Article
Language:English
Subjects:
Asphyxia neonatorum
Blood
C-reactive protein
Ferritin
Health aspects
Infants (Newborn)
Infection
Interleukins
Medical examination
Mortality
Taiwan
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Summary:Background A clinical illness known as neonatal sepsis is defined by disseminated infection symptoms and bacteremia during the first 30 days of life. It is categorized as early-onset neonatal sepsis and late-onset neonatal sepsis It is one of the leading causes of mortality and morbidity worldwide. Neonatal sepsis can be diagnosed by blood culture but it takes a lot of time. Serum ferritin as an acute phase Reactant can be used as a Marker of neonatal sepsis, also it is found to be a better indicator of mortality in neonatal sepsis. Aim Examine the diagnostic usefulness of procalcitonin, interleukin-6 (IL-6), C-reactive protein (CRP), and serum ferritin as indicators of early-onset neonatal sepsis and compare these markers with various clinical and laboratory analysis results of neonatal sepsis. Patients and methods A total of 40 newborns admitted to the Intensive Care Unit of Neonates (Ain Shams Pediatrics Hospital) took part in the study. Aged from 1 to 3 days of life, 20 neonates were proven Neonatal sepsis, and the other 20 as control Age-matched neonates without any major clinical or laboratory evidence of Sepsis. All children underwent a clinical evaluation that involved taking their history, routine investigation (CBC, CRP, and blood culture) also determination of serum ferritin, IL-6, and procalcitonin Results Procalcitonin and IL-6 both showed higher specificity as well as sensitivity than serum ferritin. Conclusion A positive correlation has been shown between CRP and serum ferritin. Furthermore, there is a positive association between procalcitonin and IL-6. Keywords: C-reactive protein, interleukin-6, neonatal sepsis, procalcitonin, serum ferritin
ISSN:1110-1067
2090-9268
DOI:10.4103/ejh.ejh_24_24