A plausibility database summarizing the level of evidence regarding the hazards induced by the exposome on children health

Childhood diseases correspond to major public health issues. A large number of studies using different approaches provide evidence regarding effects of environmental exposures, encompassed in the exposome, on children's health. We aimed to summarize the overall level of evidence (LoE) from all...

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Published in:International journal of hygiene and environmental health 2024-03, Vol.256, p.114311-114311, Article 114311
Main Authors: Stacy, Colzin, Amélie, Crépet, Blanche, Wies, Audrey, Rocabois, Margaux, Sanchez, Simon, Perreau, Julien, Jean, Matteo, Redaelli, Andreas, Kortenkamp, Christophe, Rousselle, Martine, Vrijheid, Mark, Nieuwenhuijsen, Rémy, Slama, Karine, Angeli
Format: Article
Language:English
Subjects:
Atmospheric pollutants
Chemicals
Child
Child Health
Children
Databases, Factual
Environment
Environmental Exposure
Evidence integration
Exposome
Hazard
Humans
Life Sciences
Review
Risk Assessment
Santé publique et épidémiologie
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Summary:Childhood diseases correspond to major public health issues. A large number of studies using different approaches provide evidence regarding effects of environmental exposures, encompassed in the exposome, on children's health. We aimed to summarize the overall level of evidence (LoE) from all streams of evidence regarding exposome effects on child health. For 88 selected chemical and urban factors, we retrieved the conclusions of agency reports or literature reviews published between 2015 and 2021 regarding effects on child health, including cardiovascular, metabolic, neurodevelopmental, respiratory and other health outcomes. Adapted versions of PRISMA flowchart and AMSTAR-2 tool were used to select and assess the quality of the systematic reviews retrieved from PubMed and SCOPUS databases. For each factor-outcome pair, conclusions in three streams of evidence (epidemiological, toxicological and mechanistic, the latter corresponding to in vitro and in silico approaches) were translated into stream-specific LoEs and then combined into an overall LoE ranging from “very unlikely” to “very likely”. The 88 environmental factors were implied in 611 factor-outcome pairs. Forty-four pairs (7%), corresponding to 16 factors, had a very likely overall LoE (≥80%); 127 pairs (21%), corresponding to 49 factors, had a likely or more overall LoE (≥60%). For 81 pairs (13%), no evidence was available in agency reports or published reviews, while for 275 pairs (45%), corresponding to 68 factors, the overall LoE was very unlikely (
ISSN:1438-4639
1618-131X
DOI:10.1016/j.ijheh.2023.114311