Determination of 9-hydroxyellipticine by redox colorimetry

The chemical reactions involved in the decomposition of 9-hydroxyellipticine (9-OH-E), an anticancer agent, in polar solvents is explained. The reactions, which involve the formation of 9-oxo-ellipticine and the addition of a nucleophilic acid on the C10 site of the heterocyclic system, have been us...

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Bibliographic Details
Published in:Journal of pharmaceutical and biomedical analysis 1992-06, Vol.10 (6), p.427-436
Main Authors: Formisyn, P., Pautet, F., Minh, C.Tran, Bourgois, J.
Format: Article
Language:English
Subjects:
9-Hydroxyellipticine
Analysis
Antineoplastic Agents - analysis
Antineoplastic Agents - chemistry
Biological and medical sciences
Biotechnology
Chemical and Process Engineering
Chromatography, Thin Layer - methods
Colorimetry - methods
colour measurement
Computer Science
Ellipticines - analysis
Ellipticines - chemistry
Engineering Sciences
General pharmacology
Life Sciences
mechanism of instability
Medical sciences
Oxidation-Reduction
Pharmacology. Drug treatments
qualitative and quantitative analysis
stabilization
thin-layer chromatography
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Summary:The chemical reactions involved in the decomposition of 9-hydroxyellipticine (9-OH-E), an anticancer agent, in polar solvents is explained. The reactions, which involve the formation of 9-oxo-ellipticine and the addition of a nucleophilic acid on the C10 site of the heterocyclic system, have been used to measure 9-OH-E quantitatively by colorimetry in solution and by reflection on paper surfaces. A method for the stabilization of 9-OH-E in polar solvents is proposed.
ISSN:0731-7085
1873-264X
DOI:10.1016/0731-7085(92)80061-Q