From arteriographies to computational flow in saccular aneurisms: the INRIA experience

• Published in: Medical image analysis 2005-04, Vol.9 (2), p.133-143
• Main Authors: Boissonnat, J.-D., Chaine, R., Frey, P., Malandain, G., Salmon, S., Saltel, E., Thiriet, M.
• Format: Article
• Language: English
• Subjects: 3D reconstruction; Aneurism; Angiography - methods; Blood Flow Velocity; Computer Simulation; Diagnosis, Computer-Assisted - methods; Finite element method; France; Humans; Intracranial Aneurysm - diagnosis; Intracranial Aneurysm - diagnostic imaging; Intracranial Aneurysm - physiopathology; Intracranial Aneurysm - surgery; Mathematics; Mesh adaptation; Models, Cardiovascular; Numerical Analysis; Pulsatile flow; Radiographic Image Interpretation, Computer-Assisted - methods; Surgery, Computer-Assisted - methods
• ISSN: 1361-8415; 1361-8423
• DOI: 10.1016/j.media.2004.11.004

Saccular aneurisms illustrate usefulness and possible techniques of image-based modeling of flow in diseased vessels. Aneurism flow is investigated in order to estimate the rupture risk, assuming that the pressure is the major factor and that high-pressure zones are correlated to within-wall strong-stress concentrations. Computational flow is also aimed at providing additional arguments for the treatment strategy. Angiographies of aneurismal vessels of large and medium size are processed to provide three-dimensional reconstruction of the vessel region of interest. Different reconstruction techniques are used for a side and a terminal aneurisms. Reconstruction techniques may lead to different geometries especially with poor input data. The associated facetisation is improved to get a computation-adapted surface triangulation, after a treatment of vessel ends and mesh adaptation. Once the volumic mesh is obtained, the pulsatile flow of an incompressible Newtonian blood is computed using in vivo non-invasive flowmetry and the finite element method. High pressure zones are observed in the aneurism cavity. The pressure magnitude in the aneurism, the location and the size of high pressure zones depend mainly on the aneurism implantation on the vessel wall and its orientation with respect to the blood flux in the upstream vessel. The stronger the blood impacts on the aneurismal wall the higher the pressure. The state of the aneurism neck, where a high-pressure zone can occur, and the location of the aneurism, with an easy access or not, give arguments for the choice between coiling and surgical clipping. Mesh size and 3D reconstruction procedure affect the numerical results. Helpful qualitative data are provided rather than accurate quantitative results in the context of multimodeling.