CD4 +CD25 + regulatory/suppressor T cells prevent allogeneic fetus rejection in mice

Recent evidences indicate that naturally occurring CD4 +CD25 + regulatory/suppressor T cells (T reg) regulate not only autoimmunity, but also alloreactivity. In mice, they notably control tolerance to allogeneic transplants and graft-versus-host disease after allogeneic hematopoietic stem cell trans...

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Published in:Immunology letters 2006-01, Vol.102 (1), p.106-109
Main Authors: Darasse-Jèze, Guillaume, Klatzmann, David, Charlotte, Frédéric, Salomon, Benoît L., Cohen, José L.
Format: Article
Language:English
Subjects:
Animals
Embryo Loss - immunology
Embryo Loss - prevention & control
Female
Immunoregulation
Immunoregulatory T cell
Lymph Nodes - immunology
Male
Mice
Pregnancy
Receptors, Interleukin-2 - immunology
Suppressive T cell
T-Lymphocytes, Regulatory - immunology
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container_end_page 109
container_issue 1
container_start_page 106
container_title Immunology letters
container_volume 102
creator Darasse-Jèze, Guillaume
Klatzmann, David
Charlotte, Frédéric
Salomon, Benoît L.
Cohen, José L.
description Recent evidences indicate that naturally occurring CD4 +CD25 + regulatory/suppressor T cells (T reg) regulate not only autoimmunity, but also alloreactivity. In mice, they notably control tolerance to allogeneic transplants and graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. Here, we studied the role of T reg in maternal tolerance to fetuses, i.e. natural semi-allogeneic grafts. We show that semi-allogeneic pregnancies in mice induce an expansion of T reg, but not of activated CD4 + and CD8 + T cells, in para-aortic lymph nodes draining fetal antigens. The treatment of female mice with an anti-CD25 antibody before mating results in depletion of T reg and expansion of activated CD4 + and CD8 + T cells solely in the draining lymph nodes, ultimately leading to fetus rejection. These observations were not made in the context of syngeneic pregnancies. Thus, T reg play a major role in maternal–fetal tolerance.
doi_str_mv 10.1016/j.imlet.2005.07.002
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subjects Animals
Embryo Loss - immunology
Embryo Loss - prevention & control
Female
Immunoregulation
Immunoregulatory T cell
Lymph Nodes - immunology
Male
Mice
Pregnancy
Receptors, Interleukin-2 - immunology
Suppressive T cell
T-Lymphocytes, Regulatory - immunology
title CD4 +CD25 + regulatory/suppressor T cells prevent allogeneic fetus rejection in mice
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