A method for synthesis and functionalization of ultrasmall superparamagnetic covalent carriers based on maghemite and dextran

A new generation of susceptibility contrast agents for MRI and based on maghemite cores covalently bonded to dextran stabilizing macromolecules was investigated. The multistep preparation of these versatile ultrasmall superparamagnetic iron oxides (VUSPIO) consisted of colloidal maghemite synthesis,...

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Bibliographic Details
Published in:Journal of magnetism and magnetic materials 2005-05, Vol.293 (1), p.127-134
Main Authors: Mornet, Stéphane, Portier, Josik, Duguet, Etienne
Format: Article
Language:English
Subjects:
3-Aminopropyltrimethoxysilane
[formula omitted]-Amino poly(ethylene glycol)
[formula omitted]-Diamino telechelic poly(ethylene glycol)
Chemical Sciences
Condensed matter: electronic structure, electrical, magnetic, and optical properties
Contrast agent
Dextran
Diamagnetism, paramagnetism and superparamagnetism
Exact sciences and technology
Ferrofluid
Infrared spectroscopy
Maghemite
Magnetic liquids
Magnetic properties and materials
Material chemistry
MRI
PEGylation
Photon correlation spectroscopy
Physics
Silanation
Studies of specific magnetic materials
Transmission electron microscopy
USPIO
VUSPIO
Zeta potential
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Summary:A new generation of susceptibility contrast agents for MRI and based on maghemite cores covalently bonded to dextran stabilizing macromolecules was investigated. The multistep preparation of these versatile ultrasmall superparamagnetic iron oxides (VUSPIO) consisted of colloidal maghemite synthesis, surface modification by aminopropylsilane groups, and coupling of partially oxidized dextran via Schiff's bases and secondary amine bonds. The dextran corona might be easily derivatized, e.g. by PEGylation.
ISSN:0304-8853
1873-4766
DOI:10.1016/j.jmmm.2005.01.053