Highly efficient microwave assisted α-trichlorination reaction of α-methylated nitrogen containing heterocycles

A new methodology permitting the chlorination of different α-methylated nitrogen containing heterocycles into N-α-trichloromethylated derivatives is described here. The combination of microwave technology with a PCl 5/POCl 3 protocol has allowed to reach trichloromethyl derivatives with high yields...

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Bibliographic Details
Published in:Tetrahedron 2006-08, Vol.62 (34), p.8173-8176
Main Authors: Verhaeghe, Pierre, Rathelot, Pascal, Gellis, Armand, Rault, Sylvain, Vanelle, Patrice
Format: Article
Language:English
Subjects:
Ionic polychlorination
Microwave assisted reactions
Nitrogen containing heterocycles
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Summary:A new methodology permitting the chlorination of different α-methylated nitrogen containing heterocycles into N-α-trichloromethylated derivatives is described here. The combination of microwave technology with a PCl 5/POCl 3 protocol has allowed to reach trichloromethyl derivatives with high yields in a few minutes. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2006.05.081