Neuronal and astrocytic localization of the cannabinoid receptor-1 in the dorsal horn of the rat spinal cord

Cannabinoids are involved in the control of pain at the spinal level through the cannabinoid receptor-1 (CB1) localized pre- and postsynaptically on primary afferent fibres and dorsal horn interneurones, respectively. Using immunocytochemistry, we show that in addition to its neuronal localization,...

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Bibliographic Details
Published in:Neuroscience letters 2002-08, Vol.329 (1), p.13-16
Main Authors: Salio, Chiara, Doly, Stéphane, Fischer, Jacqueline, Franzoni, Maria Fosca, Conrath, Marie
Format: Article
Language:English
Subjects:
Anatomy
Animals
Astrocytes - chemistry
Astrocytes - ultrastructure
Biological and medical sciences
Central nervous system
Fundamental and applied biological sciences. Psychology
Immunocytochemistry
Interneurons - chemistry
Interneurons - ultrastructure
Life Sciences
Male
Microscopy, Immunoelectron
Neurobiology
Neurons and Cognition
Nociceptors - physiology
Pain - metabolism
Pain control
Posterior Horn Cells - chemistry
Posterior Horn Cells - ultrastructure
Rats
Rats, Wistar
Receptors, Cannabinoid
Receptors, Drug - analysis
Ultrastructure
Vertebrates: nervous system and sense organs
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Summary:Cannabinoids are involved in the control of pain at the spinal level through the cannabinoid receptor-1 (CB1) localized pre- and postsynaptically on primary afferent fibres and dorsal horn interneurones, respectively. Using immunocytochemistry, we show that in addition to its neuronal localization, CB1 is also expressed in numerous astrocytes in laminae I and II of the rat dorsal horn. This ubiquitous localization may account for the complex role played by cannabinoids in antinociception. CB1 receptors in astrocytes may be involved in the anti-hyperalgesic action of exogenous cannabinoids.
ISSN:0304-3940
1872-7972
DOI:10.1016/S0304-3940(02)00549-9