A common somitic origin for embryonic muscle progenitors and satellite cells

In the embryo and in the adult, skeletal muscle growth is dependent on the proliferation and the differentiation of muscle progenitors present within muscle masses. Despite the importance of these progenitors, their embryonic origin is unclear. Here we use electroporation of green fluorescent protei...

Full description

Saved in:
Bibliographic Details
Published in:Nature 2005-06, Vol.435 (7044), p.954-958
Main Authors: Marcelle, Christophe, Thomé, Virginie, Gros, Jérôme, Manceau, Marie
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Biomarkers - analysis
Bromodeoxyuridine - metabolism
Cell Differentiation
Cell Lineage
Cells
Cellular Biology
Chick Embryo
Development
Embryology: invertebrates and vertebrates. Teratology
Embryos
Fundamental and applied biological sciences. Psychology
Humanities and Social Sciences
letter
Life Sciences
Molecular embryology
multidisciplinary
Muscle, Skeletal - cytology
Muscle, Skeletal - embryology
Muscle, Skeletal - metabolism
Muscles
Muscular system
Q1
Quail
satellite cells
Satellite Cells, Skeletal Muscle - cytology
Satellite Cells, Skeletal Muscle - metabolism
Science
Science (multidisciplinary)
Skeletal muscle
somites
Somites - cytology
Somites - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In the embryo and in the adult, skeletal muscle growth is dependent on the proliferation and the differentiation of muscle progenitors present within muscle masses. Despite the importance of these progenitors, their embryonic origin is unclear. Here we use electroporation of green fluorescent protein in chick somites, video confocal microscopy analysis of cell movements, and quail-chick grafting experiments to show that the dorsal compartment of the somite, the dermomyotome, is the origin of a population of muscle progenitors that contribute to the growth of trunk muscles during embryonic and fetal life. Furthermore, long-term lineage analyses indicate that satellite cells, which are known progenitors of adult skeletal muscles, derive from the same dermomyotome cell population. We conclude that embryonic muscle progenitors and satellite cells share a common origin that can be traced back to the dermomyotome.
ISSN:0028-0836
1476-4687
DOI:10.1038/nature03572