A Microwave-Assisted Heck Reaction in Poly(ethylene glycol) for the Synthesis of Benzazepines

The Heck reaction of alkylated 2‐(trimethylsilyl)ethanesulfonyl (SES)‐protected β‐amino esters provides benzazepines in good yields. Good selectivity towards cyclisation was obtained when the reaction was performed in PEG 3400 as the solvent under microwave activation. Cleavage of the SES group with...

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Published in:European Journal of Organic Chemistry 2007-01, Vol.2007 (1), p.201-208
Main Authors: Declerck, Valérie, Ribière, Patrice, Nédellec, Yannig, Allouchi, Hassan, Martinez, Jean, Lamaty, Frédéric
Format: Article
Language:English
Subjects:
Chemical Sciences
Microwaves
Nanoparticles
Nitrogen heterocycles
Organic chemistry
Palladium
Solvent effects
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creator Declerck, Valérie
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description The Heck reaction of alkylated 2‐(trimethylsilyl)ethanesulfonyl (SES)‐protected β‐amino esters provides benzazepines in good yields. Good selectivity towards cyclisation was obtained when the reaction was performed in PEG 3400 as the solvent under microwave activation. Cleavage of the SES group with HF provides the corresponding free benzazepine. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
doi_str_mv 10.1002/ejoc.200600680
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subjects Chemical Sciences
Microwaves
Nanoparticles
Nitrogen heterocycles
Organic chemistry
Palladium
Solvent effects
title A Microwave-Assisted Heck Reaction in Poly(ethylene glycol) for the Synthesis of Benzazepines
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