Microwaves Make Hydroformylation a Rapid and Easy Process

Hydroformylation of alkenes can be carried out in a few minutes under microwave activation at a relatively low pressure (40 psi) using commercially available catalysts and ligands. The 80 mL vial of a Discover microwave oven was connected to a cylinder of CO and H2, and after filling the reactor at...

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Bibliographic Details
Published in:Organic letters 2006-08, Vol.8 (17), p.3725-3727
Main Authors: Petricci, Elena, Mann, André, Schoenfelder, Angèle, Rota, Andrea, Taddei, Maurizio
Format: Article
Language:English
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Summary:Hydroformylation of alkenes can be carried out in a few minutes under microwave activation at a relatively low pressure (40 psi) using commercially available catalysts and ligands. The 80 mL vial of a Discover microwave oven was connected to a cylinder of CO and H2, and after filling the reactor at 40 psi, a mixture of an alkene, the Wilkinson catalyst, and XANTPHOS was submitted to microwave irradiation giving, after 4 min, high conversion into the corresponding aldehyde without formation of the isomerized alkene.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol061312v