Production of 5alpha-reduced neurosteroids is developmentally regulated and shapes GABAA miniature IPSCs in lamina II of the spinal cord

In lamina II of the spinal dorsal horn, synaptic inhibition mediated by ionotropic GABA(A) and glycine receptors contributes to the integration of peripheral nociceptive messages. Whole-cell patch-clamp recordings were performed from lamina II neurons in spinal cord slices to study the properties of...

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Bibliographic Details
Published in:The Journal of neuroscience 2004, Vol.24 (4), p.907-915
Main Authors: Keller, Anne Florence, Breton, Jean-Didier, Schlichter, Rémy, Poisbeau, Pierrick
Format: Article
Language:English
Subjects:
Life Sciences
Neurons and Cognition
Online Access:Get full text
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Summary:In lamina II of the spinal dorsal horn, synaptic inhibition mediated by ionotropic GABA(A) and glycine receptors contributes to the integration of peripheral nociceptive messages. Whole-cell patch-clamp recordings were performed from lamina II neurons in spinal cord slices to study the properties of miniature IPSCs (mIPSCs) mediated by activation of GABA(A) and glycine receptors in immature (
ISSN:0270-6474
1529-2401