Cell vesiculation and immunopathology: implications in cerebral malaria

Microparticles are plasma membrane fragments that are generated and released under physiological conditions. They are also released when tissue and/or systemic homeostasis is disrupted. These microparticles display different physiological features of the cells from which they originate. They are det...

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Bibliographic Details
Published in:Microbes and infection 2006-07, Vol.8 (8), p.2305-2316
Main Authors: Coltel, Nicolas, Combes, Valéry, Wassmer, Samuel C., Chimini, Giovanna, Grau, Georges E.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cell Membrane
Cell Membrane - metabolism
Cell Membrane - ultrastructure
Cerebral malaria
Fundamental and applied biological sciences. Psychology
Human protozoal diseases
Humans
Immunology
Immunopathology
Infection
Infection - immunology
Infection - pathology
Infectious diseases
Inflammation
Inflammation - immunology
Inflammation - pathology
Life Sciences
Malaria
Malaria, Cerebral
Malaria, Cerebral - immunology
Malaria, Cerebral - pathology
Medical sciences
Microbiology
Microparticles
Models, Biological
Parasitic diseases
Protozoal diseases
Vesiculation
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Summary:Microparticles are plasma membrane fragments that are generated and released under physiological conditions. They are also released when tissue and/or systemic homeostasis is disrupted. These microparticles display different physiological features of the cells from which they originate. They are detected in some pathological conditions, but rarely suspected of participating in the disease's pathogenesis. In the present review, we summarise data about the production of the microparticles, their biological significance and potential role during microorganism-driven processes, especially in cerebral malaria.
ISSN:1286-4579
1769-714X
DOI:10.1016/j.micinf.2006.04.006