Synthesis of pyochelin–norfloxacin conjugates

Using synthetic functionalized analogues of pyochelin, a siderophore common to several pathogenic Pseudomonas and Burkholderia species, four fluoroquinolone-pyochelin conjugates were efficiently synthesized and evaluated for their biological activities.

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2007-02, Vol.17 (3), p.640-644
Main Authors: Rivault, Freddy, Liébert, Clémence, Burger, Alain, Hoegy, Françoise, Abdallah, Mohamed A., Schalk, Isabelle J., Mislin, Gaëtan L.A.
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents
Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biochemistry, Molecular Biology
Biological and medical sciences
Burkholderia
Burkholderia cepacia
Burkholderia cepacia - drug effects
Cystic fibrosis
Fluoroquinolone
Iron Chelating Agents
Iron Chelating Agents - pharmacology
Iron uptake
Life Sciences
Magnetic Resonance Spectroscopy
Medical sciences
Microbial Sensitivity Tests
Norfloxacin
Norfloxacin - chemistry
Norfloxacin - pharmacology
Pharmacology. Drug treatments
Phenols
Phenols - chemistry
Phenols - pharmacology
Pseudomonas
Pseudomonas aeruginosa
Pseudomonas aeruginosa - drug effects
Pyochelin
Siderophore
Structure-Activity Relationship
Thiazoles
Thiazoles - chemistry
Thiazoles - pharmacology
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Description
Summary:Using synthetic functionalized analogues of pyochelin, a siderophore common to several pathogenic Pseudomonas and Burkholderia species, four fluoroquinolone-pyochelin conjugates were efficiently synthesized and evaluated for their biological activities.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2006.11.005