Centromeric protein CENP-B proteasomal degradation induced by the viral protein ICP0

The ICP0 protein of herpes simplex virus type 1 (HSV-1) is a nuclear protein that possesses a well-characterized E3 ubiquitin ligase activity. This activity is responsible for the proteasomal-dependent degradation of several cellular proteins. This study shows that ICP0 induces the proteasomal-depen...

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Bibliographic Details
Published in:FEBS letters 2007-02, Vol.581 (4), p.658-662
Main Authors: Lomonte, Patrick, Morency, Eric
Format: Article
Language:English
Subjects:
Animals
CENP-B
Centromere Protein B
Centromere Protein B - metabolism
Centromeres
Genetics
HeLa Cells
Herpes simplex virus 1
HSV-1
Humans
ICP0
Immediate-Early Proteins
Immediate-Early Proteins - metabolism
Life Sciences
Mice
NIH 3T3 Cells
Nucleus
Proteasome Endopeptidase Complex
Proteasome Endopeptidase Complex - metabolism
Protein Processing, Post-Translational
Ubiquitin-Protein Ligases
Ubiquitin-Protein Ligases - metabolism
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Summary:The ICP0 protein of herpes simplex virus type 1 (HSV-1) is a nuclear protein that possesses a well-characterized E3 ubiquitin ligase activity. This activity is responsible for the proteasomal-dependent degradation of several cellular proteins. This study shows that ICP0 induces the proteasomal-dependent degradation of the centromeric protein CENP-B in infected as well as ICP0-expressing cells. It is also shown that the ICP0-induced CENP-B degradation occurs as efficiently in human and mouse cells. CENP-B is one of the major proteins of centromeres and its degradation is likely to contribute to the severe damage induced to centromeres by ICP0.
ISSN:0014-5793
1873-3468
DOI:10.1016/j.febslet.2007.01.027