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Centromeric protein CENP-B proteasomal degradation induced by the viral protein ICP0

The ICP0 protein of herpes simplex virus type 1 (HSV-1) is a nuclear protein that possesses a well-characterized E3 ubiquitin ligase activity. This activity is responsible for the proteasomal-dependent degradation of several cellular proteins. This study shows that ICP0 induces the proteasomal-depen...

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Published in:	FEBS letters 2007-02, Vol.581 (4), p.658-662
Main Authors:	Lomonte, Patrick, Morency, Eric
Format:	Article
Language:	English
Subjects:	Animals CENP-B Centromere Protein B Centromere Protein B - metabolism Centromeres Genetics HeLa Cells Herpes simplex virus 1 HSV-1 Humans ICP0 Immediate-Early Proteins Immediate-Early Proteins - metabolism Life Sciences Mice NIH 3T3 Cells Nucleus Proteasome Endopeptidase Complex Proteasome Endopeptidase Complex - metabolism Protein Processing, Post-Translational Ubiquitin-Protein Ligases Ubiquitin-Protein Ligases - metabolism
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description	The ICP0 protein of herpes simplex virus type 1 (HSV-1) is a nuclear protein that possesses a well-characterized E3 ubiquitin ligase activity. This activity is responsible for the proteasomal-dependent degradation of several cellular proteins. This study shows that ICP0 induces the proteasomal-dependent degradation of the centromeric protein CENP-B in infected as well as ICP0-expressing cells. It is also shown that the ICP0-induced CENP-B degradation occurs as efficiently in human and mouse cells. CENP-B is one of the major proteins of centromeres and its degradation is likely to contribute to the severe damage induced to centromeres by ICP0.
doi_str_mv	10.1016/j.febslet.2007.01.027
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subjects	Animals CENP-B Centromere Protein B Centromere Protein B - metabolism Centromeres Genetics HeLa Cells Herpes simplex virus 1 HSV-1 Humans ICP0 Immediate-Early Proteins Immediate-Early Proteins - metabolism Life Sciences Mice NIH 3T3 Cells Nucleus Proteasome Endopeptidase Complex Proteasome Endopeptidase Complex - metabolism Protein Processing, Post-Translational Ubiquitin-Protein Ligases Ubiquitin-Protein Ligases - metabolism
title	Centromeric protein CENP-B proteasomal degradation induced by the viral protein ICP0
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