Transcriptional coregulators in the control of energy homeostasis

Metabolic programs controlling energy homeostasis are governed at the transcriptional level by the integrated action of several transcription factors. Among these, nuclear receptors including peroxisome proliferator-activated receptors, estrogen-related receptors or thyroid hormone receptors play pr...

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Bibliographic Details
Published in:Trends in cell biology 2007-06, Vol.17 (6), p.292-301
Main Authors: Feige, Jérôme N, Auwerx, Johan
Format: Article
Language:English
Subjects:
Adaptor Proteins, Signal Transducing
Adaptor Proteins, Signal Transducing - metabolism
Adipogenesis
Adipogenesis - physiology
Animals
Biochemistry, Molecular Biology
CREB-Binding Protein
CREB-Binding Protein - metabolism
Energy Metabolism
Gene Expression Regulation
Homeostasis
Life Sciences
Molecular biology
Muscles
Muscles - cytology
Muscles - metabolism
Nuclear Proteins
Nuclear Proteins - metabolism
Pathology
PPAR gamma
PPAR gamma - metabolism
Transcription Factors
Transcription Factors - metabolism
Transcription, Genetic
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Summary:Metabolic programs controlling energy homeostasis are governed at the transcriptional level by the integrated action of several transcription factors. Among these, nuclear receptors including peroxisome proliferator-activated receptors, estrogen-related receptors or thyroid hormone receptors play prominent roles by adapting gene expression programs to the endocrine and metabolic context that they sense via their ligand-binding domain. Coregulators assist nuclear receptors to positively or negatively influence the transcription of target genes, and thereby comprise an integral part of the transcriptional circuitry. This review focuses on how coregulators, including PGC-1 and p160 coactivators, Sirt-1, RIP140 and NCoR corepressors, control the balance between energy storage and expenditure, with a particular emphasis on how these proteins integrate physiological stimuli in vivo . The general picture that emerges indicates that these coregulators are metabolic switches, which convergently regulate metabolic pathways through their pleiotropic interactions with nuclear receptors and other transcription factors.
ISSN:0962-8924
1879-3088
DOI:10.1016/j.tcb.2007.04.001