Silylation of triacylglycerol: an easy route to new biosiloxanes

A new approach to functionalize triacylglycerol fish oils has been achieved. For the first time, hydrosilylation of various terminal and internal C C double bonds in ethylenic triacylglycerol was performed under radical initiation sequence, which, after ethanolysis, gave the sol–gel processable trie...

Full description

Saved in:
Bibliographic Details
Published in:Chemistry and physics of lipids 2007-08, Vol.148 (2), p.112-120
Main Authors: El Kadib, Abdelkrim, Castel, Annie, Delpech, Fabien, Rivière, Pierre
Format: Article
Language:English
Subjects:
Chemical Sciences
Drug Delivery Systems - methods
Ethanol - chemistry
Fish Oils - chemistry
Gels - chemistry
Hydrolysis
Organic chemistry
Pharmaceutical Preparations - chemistry
Silanes - chemistry
Siloxanes - chemical synthesis
Silylation
Solubility
Sol–gel hydrolysis
Triacylglycerol
Triglycerides - chemistry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A new approach to functionalize triacylglycerol fish oils has been achieved. For the first time, hydrosilylation of various terminal and internal C C double bonds in ethylenic triacylglycerol was performed under radical initiation sequence, which, after ethanolysis, gave the sol–gel processable triethoxysilyltriacylglycerol P 2 . By the use of silyltriflate, new metalated triglycerides P 3 , in which silyl fragments are C -bonded in α-position to glycerol groups, were synthesized. The sol–gel hydrolysis and polycondensation of triethoxysilyltriacylglycerol led to hybrid materials in which organic and inorganic moieties are covalently linked. These materials open new applications in drug delivery and pharmaceutical formulation.
ISSN:0009-3084
1873-2941
DOI:10.1016/j.chemphyslip.2007.05.002