A genetic programme for neuronal connectivity

What is the nature of the genetic programme that allows neurons to extend their axons and connect to other neurons with a high degree of specificity? Work on the sensory neurons of the fly has shown how the control of neuronal identity is embedded in the general developmental programme of the organi...

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Bibliographic Details
Published in:Trends in genetics 2000-05, Vol.16 (5), p.221-226
Main Authors: GHYSEN, A, DAMBLY-CHAUDIERE, C
Format: Article
Language:English
Subjects:
Animals
Axons
Axons - physiology
Biological and medical sciences
Cell physiology
Development Biology
Drosophila
Drosophila - genetics
Drosophila - growth & development
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation, Developmental
Life Sciences
Molecular and cellular biology
Mutation
Neurons
Neurons - physiology
Neurons, Afferent
Neurons, Afferent - physiology
Neurotransmission
Sense Organs
Sense Organs - growth & development
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Summary:What is the nature of the genetic programme that allows neurons to extend their axons and connect to other neurons with a high degree of specificity? Work on the sensory neurons of the fly has shown how the control of neuronal identity is embedded in the general developmental programme of the organism. The ongoing analysis of pathfinding mutants suggests plausible mechanisms for the translation of neuronal identity into axonal behaviour.
ISSN:0168-9525
DOI:10.1016/S0168-9525(99)01969-1