Cell proliferation in the developing lateral line system of zebrafish embryos

The sensory organs of the embryonic lateral line system are deposited by migrating primordia that originate in the otic region. Here, we examine the pattern of cell proliferation in the posterior lateral line system. We conclude that three phases of cell proliferation are involved in the generation...

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Bibliographic Details
Published in:Developmental dynamics 2005-06, Vol.233 (2), p.466-472
Main Authors: Laguerre, Laurent, Soubiran, Fabien, Ghysen, Alain, König, Norbert, Dambly‐Chaudière, Christine
Format: Article
Language:English
Subjects:
Animals
Body Patterning
Body Patterning - physiology
BrdU
Bromodeoxyuridine
cell migration
Cell Movement
Cell Proliferation
Danio rerio
Development Biology
Embryo, Nonmammalian
Embryo, Nonmammalian - cytology
Embryo, Nonmammalian - embryology
Functional Laterality
Life Sciences
mitotic quiescence
neuromasts
primordium
proneural genes
Zebrafish
Zebrafish - embryology
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Summary:The sensory organs of the embryonic lateral line system are deposited by migrating primordia that originate in the otic region. Here, we examine the pattern of cell proliferation in the posterior lateral line system. We conclude that three phases of cell proliferation are involved in the generation of this system, separated by two phases of mitotic quiescence. The first phase corresponds to generalized proliferation during gastrulation, followed by a first period of quiescence that may be related to the determination of the lateral line precursor cells. A second phase of proliferation takes place in the placode and migrating primordium. This region is organized in annuli that correspond to the expression of proneural/neurogenic genes. A second period of quiescence follows, corresponding to deposition and differentiation of the sensory organs. The third period of proliferation corresponds to continued renewal of hair cells by division of support cells within each sensory organ. Developmental Dynamics 233:466–472, 2005. © 2005 Wiley‐Liss, Inc.
ISSN:1058-8388
1097-0177
DOI:10.1002/dvdy.20343