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Daily intake of conjugated linoleic acid-enriched yoghurts: effects on energy metabolism and adipose tissue gene expression in healthy subjects
Conjugated linoleic acid (CLA) is a group of positional and geometric isomers of conjugated dienoic derivatives of linoleic acid. The present study was designed to determine whether 14-week CLA supplementation as triacylglycerols (3·76 g) with a 50 : 50 combination of the two main isomers (35 % cis-...
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| Published in: | British journal of nutrition 2007-02, Vol.97 (2), p.273-280 |
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| cites | cdi_FETCH-LOGICAL-c598t-a75bcf2879fc68d1afdb368f27e9496190254c1b33bcf85303c484617f1a91733 |
| container_end_page | 280 |
| container_issue | 2 |
| container_start_page | 273 |
| container_title | British journal of nutrition |
| container_volume | 97 |
| creator | Nazare, Julie-Anne Perrière, Aude Brac de la Bonnet, Fabrice Desage, Michel Peyrat, Jocelyne Maitrepierre, Christine Louche-Pelissier, Corinne Bruzeau, Joëlle Goudable, Joëlle Lassel, Taous Vidal, Hubert Laville, Martine |
| description | Conjugated linoleic acid (CLA) is a group of positional and geometric isomers of conjugated dienoic derivatives of linoleic acid. The present study was designed to determine whether 14-week CLA supplementation as triacylglycerols (3·76 g) with a 50 : 50 combination of the two main isomers (35 % cis-9, trans-11 and 35 % trans-10, cis-12) added to flavoured yoghurt-like products was able to alter body composition in healthy subjects and to alter the expression of several key adipose tissue genes (PPAR γ, lipoprotein lipase (LPL), hormone-sensitive lipase (HSL) and uncoupling protein 2 (UCP-2)). Forty-four healthy subjects were randomly assigned to consume daily either a CLA-supplemented yoghurt-like product or a placebo yoghurt for 98 d. There were no significant effects of CLA supplementation on body weight, fat mass or free fat mass. Basal energy expenditure expressed as kg free fat mass increased significantly in the CLA group (123·3 (sem 2·5) kJ/kg free fat mass per d on day 98 v. 118·7 (sem 2·3) kJ/kg free fat mass per d on day 0, P = 0·03). PPAR γ mRNA gene expression increased significantly with CLA supplementation (53 (sem 20) %, P |
| doi_str_mv | 10.1017/S0007114507191911 |
| format | article |
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The present study was designed to determine whether 14-week CLA supplementation as triacylglycerols (3·76 g) with a 50 : 50 combination of the two main isomers (35 % cis-9, trans-11 and 35 % trans-10, cis-12) added to flavoured yoghurt-like products was able to alter body composition in healthy subjects and to alter the expression of several key adipose tissue genes (PPAR γ, lipoprotein lipase (LPL), hormone-sensitive lipase (HSL) and uncoupling protein 2 (UCP-2)). Forty-four healthy subjects were randomly assigned to consume daily either a CLA-supplemented yoghurt-like product or a placebo yoghurt for 98 d. There were no significant effects of CLA supplementation on body weight, fat mass or free fat mass. Basal energy expenditure expressed as kg free fat mass increased significantly in the CLA group (123·3 (sem 2·5) kJ/kg free fat mass per d on day 98 v. 118·7 (sem 2·3) kJ/kg free fat mass per d on day 0, P = 0·03). PPAR γ mRNA gene expression increased significantly with CLA supplementation (53 (sem 20) %, P < 0·01) and a significant reduction in mRNA levels of HSL was observed ( − 42 (sem 7) %, P = 0·01). The levels of UCP-2 and LPL mRNA were not affected. The present results suggest that a 98 d supplementation diet with a 50 : 50 mixture of the two CLA isomers cis-9, trans-11 and trans-10, cis-12 in a dairy product was unable to alter body composition, although a significant increase in the RMR has been induced. Moreover, changes in mRNA PPAR γ and HSL in adipose tissue were recorded.</description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1017/S0007114507191911</identifier><identifier>PMID: 17298695</identifier><identifier>CODEN: BJNUAV</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Acids ; Adipocytes ; Adipose tissue ; Adipose Tissue - physiology ; Adipose tissue gene expression ; Adult ; adults ; animal proteins ; basal metabolism ; Biological and medical sciences ; Biopsy ; Blood Glucose - analysis ; Body composition ; Body Composition - physiology ; Body fat ; Body mass index ; Body weight ; carboxylic ester hydrolases ; Conjugated linoleic acid ; Dairy products ; Diet ; Dietary Supplements ; domain_sdv.ida.ing ; domain_sdv.ida.ing.lip ; Double-Blind Method ; Energy ; Energy expenditure ; Energy metabolism ; Energy Metabolism - physiology ; enriched foods ; Enzymes ; fat free mass ; Fatty acids ; Fatty Acids - analysis ; Feeding. Feeding behavior ; Female ; Food engineering ; Fundamental and applied biological sciences. Psychology ; Gene expression ; Gene Expression - physiology ; Glucose ; Health ; hormone-sensitive lipase ; Humans ; Insulin - blood ; Ion Channels - genetics ; Isomers ; Leptin - blood ; Life Sciences ; Linoleic acid ; Linoleic Acids, Conjugated - administration & dosage ; Lipase ; Lipids ; Lipids - blood ; Lipoprotein lipase ; Lipoprotein Lipase - genetics ; Male ; Metabolism ; Mitochondrial Proteins - genetics ; Mitochondrial uncoupling protein 2 ; Nitrogen ; Nutrition ; Nutrition research ; Obesity ; Overweight ; Oxidation ; Peroxisome proliferator-activated receptors ; Plasma ; PPAR gamma - genetics ; Sterol Esterase - genetics ; Studies ; Tissues ; transcription factors ; triacylglycerols ; Triglycerides ; Uncoupling Agents ; Uncoupling Protein 2 ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Yogurt</subject><ispartof>British journal of nutrition, 2007-02, Vol.97 (2), p.273-280</ispartof><rights>Copyright © The Authors 2007</rights><rights>2007 INIST-CNRS</rights><rights>The Authors</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c598t-a75bcf2879fc68d1afdb368f27e9496190254c1b33bcf85303c484617f1a91733</citedby><cites>FETCH-LOGICAL-c598t-a75bcf2879fc68d1afdb368f27e9496190254c1b33bcf85303c484617f1a91733</cites><orcidid>0000-0001-9255-8228 ; 0000-0003-3545-3264 ; 0000-0002-9467-0317</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0007114507191911/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,72960</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18511822$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17298695$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00294435$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Nazare, Julie-Anne</creatorcontrib><creatorcontrib>Perrière, Aude Brac de la</creatorcontrib><creatorcontrib>Bonnet, Fabrice</creatorcontrib><creatorcontrib>Desage, Michel</creatorcontrib><creatorcontrib>Peyrat, Jocelyne</creatorcontrib><creatorcontrib>Maitrepierre, Christine</creatorcontrib><creatorcontrib>Louche-Pelissier, Corinne</creatorcontrib><creatorcontrib>Bruzeau, Joëlle</creatorcontrib><creatorcontrib>Goudable, Joëlle</creatorcontrib><creatorcontrib>Lassel, Taous</creatorcontrib><creatorcontrib>Vidal, Hubert</creatorcontrib><creatorcontrib>Laville, Martine</creatorcontrib><title>Daily intake of conjugated linoleic acid-enriched yoghurts: effects on energy metabolism and adipose tissue gene expression in healthy subjects</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>Conjugated linoleic acid (CLA) is a group of positional and geometric isomers of conjugated dienoic derivatives of linoleic acid. The present study was designed to determine whether 14-week CLA supplementation as triacylglycerols (3·76 g) with a 50 : 50 combination of the two main isomers (35 % cis-9, trans-11 and 35 % trans-10, cis-12) added to flavoured yoghurt-like products was able to alter body composition in healthy subjects and to alter the expression of several key adipose tissue genes (PPAR γ, lipoprotein lipase (LPL), hormone-sensitive lipase (HSL) and uncoupling protein 2 (UCP-2)). Forty-four healthy subjects were randomly assigned to consume daily either a CLA-supplemented yoghurt-like product or a placebo yoghurt for 98 d. There were no significant effects of CLA supplementation on body weight, fat mass or free fat mass. Basal energy expenditure expressed as kg free fat mass increased significantly in the CLA group (123·3 (sem 2·5) kJ/kg free fat mass per d on day 98 v. 118·7 (sem 2·3) kJ/kg free fat mass per d on day 0, P = 0·03). PPAR γ mRNA gene expression increased significantly with CLA supplementation (53 (sem 20) %, P < 0·01) and a significant reduction in mRNA levels of HSL was observed ( − 42 (sem 7) %, P = 0·01). The levels of UCP-2 and LPL mRNA were not affected. The present results suggest that a 98 d supplementation diet with a 50 : 50 mixture of the two CLA isomers cis-9, trans-11 and trans-10, cis-12 in a dairy product was unable to alter body composition, although a significant increase in the RMR has been induced. Moreover, changes in mRNA PPAR γ and HSL in adipose tissue were recorded.</description><subject>Acids</subject><subject>Adipocytes</subject><subject>Adipose tissue</subject><subject>Adipose Tissue - physiology</subject><subject>Adipose tissue gene expression</subject><subject>Adult</subject><subject>adults</subject><subject>animal proteins</subject><subject>basal metabolism</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Blood Glucose - analysis</subject><subject>Body composition</subject><subject>Body Composition - physiology</subject><subject>Body fat</subject><subject>Body mass index</subject><subject>Body weight</subject><subject>carboxylic ester hydrolases</subject><subject>Conjugated linoleic acid</subject><subject>Dairy products</subject><subject>Diet</subject><subject>Dietary Supplements</subject><subject>domain_sdv.ida.ing</subject><subject>domain_sdv.ida.ing.lip</subject><subject>Double-Blind Method</subject><subject>Energy</subject><subject>Energy expenditure</subject><subject>Energy metabolism</subject><subject>Energy Metabolism - physiology</subject><subject>enriched foods</subject><subject>Enzymes</subject><subject>fat free mass</subject><subject>Fatty acids</subject><subject>Fatty Acids - analysis</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Food engineering</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene expression</subject><subject>Gene Expression - physiology</subject><subject>Glucose</subject><subject>Health</subject><subject>hormone-sensitive lipase</subject><subject>Humans</subject><subject>Insulin - blood</subject><subject>Ion Channels - genetics</subject><subject>Isomers</subject><subject>Leptin - blood</subject><subject>Life Sciences</subject><subject>Linoleic acid</subject><subject>Linoleic Acids, Conjugated - administration & dosage</subject><subject>Lipase</subject><subject>Lipids</subject><subject>Lipids - blood</subject><subject>Lipoprotein lipase</subject><subject>Lipoprotein Lipase - genetics</subject><subject>Male</subject><subject>Metabolism</subject><subject>Mitochondrial Proteins - genetics</subject><subject>Mitochondrial uncoupling protein 2</subject><subject>Nitrogen</subject><subject>Nutrition</subject><subject>Nutrition research</subject><subject>Obesity</subject><subject>Overweight</subject><subject>Oxidation</subject><subject>Peroxisome proliferator-activated receptors</subject><subject>Plasma</subject><subject>PPAR gamma - genetics</subject><subject>Sterol Esterase - genetics</subject><subject>Studies</subject><subject>Tissues</subject><subject>transcription factors</subject><subject>triacylglycerols</subject><subject>Triglycerides</subject><subject>Uncoupling Agents</subject><subject>Uncoupling Protein 2</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Yogurt</subject><issn>0007-1145</issn><issn>1475-2662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNqF0t1q1EAUB_Agiq3VB_BGh4qCF9H5yHx5V6tthUWRbSl4M0wmM9nZJpl1JpHuU_jKzrJLF5QigYTM-Z1D_uEUxXME3yGI-Ps5hJAjVNF8l_lCD4pDVHFaYsbww-JwUy439YPiSUrL_CoQlI-LA8SxFEzSw-L3J-27NfDDqG8sCA6YMCynVo-2AZ0fQme9Adr4prRD9GaRj9ehXUxxTB-Adc6aMYEwADvY2K5Bb0ddh86nHuihAbrxq5AsGH1KkwVtVsDerqJNyecmP4CF1d24WIM01cvNrKfFI6e7ZJ_tnkfF1dnny9OLcvbt_Mvpyaw0VIqx1JzWxmHBpTNMNEi7piZMOMytrCRDEmJaGVQTkpmgBBJTiYoh7pCWiBNyVLzdzl3oTq2i73Vcq6C9ujiZqc0ZhFhWFaG_ULZvtnYVw8_JplH1PhnbdXqwYUqKSQjzzyf_hRhCyilkGb76Cy7DFIccWGFBqIBCCp7V8b0KEUGQlDIjtEUmhpSidXdpEFSbLVH_bEnuebEbPNW9bfYdu7XI4PUO6GR056IejE97JyhCAuPsyq3zabS3d3UdbxTjhFPFzr-rs-uv8x8fr5m6zP7l1jsdlG5jnnk1xxCR_IWM82qTmezi6L6OvmntPvT9gf4APtnrQQ</recordid><startdate>20070201</startdate><enddate>20070201</enddate><creator>Nazare, Julie-Anne</creator><creator>Perrière, Aude Brac de la</creator><creator>Bonnet, Fabrice</creator><creator>Desage, Michel</creator><creator>Peyrat, Jocelyne</creator><creator>Maitrepierre, Christine</creator><creator>Louche-Pelissier, Corinne</creator><creator>Bruzeau, Joëlle</creator><creator>Goudable, Joëlle</creator><creator>Lassel, Taous</creator><creator>Vidal, Hubert</creator><creator>Laville, Martine</creator><general>Cambridge University Press</general><general>Cambridge University Press (CUP)</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7T5</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0001-9255-8228</orcidid><orcidid>https://orcid.org/0000-0003-3545-3264</orcidid><orcidid>https://orcid.org/0000-0002-9467-0317</orcidid></search><sort><creationdate>20070201</creationdate><title>Daily intake of conjugated linoleic acid-enriched yoghurts: effects on energy metabolism and adipose tissue gene expression in healthy subjects</title><author>Nazare, Julie-Anne ; Perrière, Aude Brac de la ; Bonnet, Fabrice ; Desage, Michel ; Peyrat, Jocelyne ; Maitrepierre, Christine ; Louche-Pelissier, Corinne ; Bruzeau, Joëlle ; Goudable, Joëlle ; Lassel, Taous ; Vidal, Hubert ; Laville, Martine</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c598t-a75bcf2879fc68d1afdb368f27e9496190254c1b33bcf85303c484617f1a91733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Acids</topic><topic>Adipocytes</topic><topic>Adipose tissue</topic><topic>Adipose Tissue - physiology</topic><topic>Adipose tissue gene expression</topic><topic>Adult</topic><topic>adults</topic><topic>animal proteins</topic><topic>basal metabolism</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Blood Glucose - analysis</topic><topic>Body composition</topic><topic>Body Composition - physiology</topic><topic>Body fat</topic><topic>Body mass index</topic><topic>Body weight</topic><topic>carboxylic ester hydrolases</topic><topic>Conjugated linoleic acid</topic><topic>Dairy products</topic><topic>Diet</topic><topic>Dietary Supplements</topic><topic>domain_sdv.ida.ing</topic><topic>domain_sdv.ida.ing.lip</topic><topic>Double-Blind Method</topic><topic>Energy</topic><topic>Energy expenditure</topic><topic>Energy metabolism</topic><topic>Energy Metabolism - physiology</topic><topic>enriched foods</topic><topic>Enzymes</topic><topic>fat free mass</topic><topic>Fatty acids</topic><topic>Fatty Acids - analysis</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Food engineering</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene expression</topic><topic>Gene Expression - physiology</topic><topic>Glucose</topic><topic>Health</topic><topic>hormone-sensitive lipase</topic><topic>Humans</topic><topic>Insulin - blood</topic><topic>Ion Channels - genetics</topic><topic>Isomers</topic><topic>Leptin - blood</topic><topic>Life Sciences</topic><topic>Linoleic acid</topic><topic>Linoleic Acids, Conjugated - administration & dosage</topic><topic>Lipase</topic><topic>Lipids</topic><topic>Lipids - blood</topic><topic>Lipoprotein lipase</topic><topic>Lipoprotein Lipase - genetics</topic><topic>Male</topic><topic>Metabolism</topic><topic>Mitochondrial Proteins - genetics</topic><topic>Mitochondrial uncoupling protein 2</topic><topic>Nitrogen</topic><topic>Nutrition</topic><topic>Nutrition research</topic><topic>Obesity</topic><topic>Overweight</topic><topic>Oxidation</topic><topic>Peroxisome proliferator-activated receptors</topic><topic>Plasma</topic><topic>PPAR gamma - genetics</topic><topic>Sterol Esterase - genetics</topic><topic>Studies</topic><topic>Tissues</topic><topic>transcription factors</topic><topic>triacylglycerols</topic><topic>Triglycerides</topic><topic>Uncoupling Agents</topic><topic>Uncoupling Protein 2</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Yogurt</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nazare, Julie-Anne</creatorcontrib><creatorcontrib>Perrière, Aude Brac de la</creatorcontrib><creatorcontrib>Bonnet, Fabrice</creatorcontrib><creatorcontrib>Desage, Michel</creatorcontrib><creatorcontrib>Peyrat, Jocelyne</creatorcontrib><creatorcontrib>Maitrepierre, Christine</creatorcontrib><creatorcontrib>Louche-Pelissier, Corinne</creatorcontrib><creatorcontrib>Bruzeau, Joëlle</creatorcontrib><creatorcontrib>Goudable, Joëlle</creatorcontrib><creatorcontrib>Lassel, Taous</creatorcontrib><creatorcontrib>Vidal, Hubert</creatorcontrib><creatorcontrib>Laville, Martine</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Agriculture Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>British journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nazare, Julie-Anne</au><au>Perrière, Aude Brac de la</au><au>Bonnet, Fabrice</au><au>Desage, Michel</au><au>Peyrat, Jocelyne</au><au>Maitrepierre, Christine</au><au>Louche-Pelissier, Corinne</au><au>Bruzeau, Joëlle</au><au>Goudable, Joëlle</au><au>Lassel, Taous</au><au>Vidal, Hubert</au><au>Laville, Martine</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Daily intake of conjugated linoleic acid-enriched yoghurts: effects on energy metabolism and adipose tissue gene expression in healthy subjects</atitle><jtitle>British journal of nutrition</jtitle><addtitle>Br J Nutr</addtitle><date>2007-02-01</date><risdate>2007</risdate><volume>97</volume><issue>2</issue><spage>273</spage><epage>280</epage><pages>273-280</pages><issn>0007-1145</issn><eissn>1475-2662</eissn><coden>BJNUAV</coden><abstract>Conjugated linoleic acid (CLA) is a group of positional and geometric isomers of conjugated dienoic derivatives of linoleic acid. The present study was designed to determine whether 14-week CLA supplementation as triacylglycerols (3·76 g) with a 50 : 50 combination of the two main isomers (35 % cis-9, trans-11 and 35 % trans-10, cis-12) added to flavoured yoghurt-like products was able to alter body composition in healthy subjects and to alter the expression of several key adipose tissue genes (PPAR γ, lipoprotein lipase (LPL), hormone-sensitive lipase (HSL) and uncoupling protein 2 (UCP-2)). Forty-four healthy subjects were randomly assigned to consume daily either a CLA-supplemented yoghurt-like product or a placebo yoghurt for 98 d. There were no significant effects of CLA supplementation on body weight, fat mass or free fat mass. Basal energy expenditure expressed as kg free fat mass increased significantly in the CLA group (123·3 (sem 2·5) kJ/kg free fat mass per d on day 98 v. 118·7 (sem 2·3) kJ/kg free fat mass per d on day 0, P = 0·03). PPAR γ mRNA gene expression increased significantly with CLA supplementation (53 (sem 20) %, P < 0·01) and a significant reduction in mRNA levels of HSL was observed ( − 42 (sem 7) %, P = 0·01). The levels of UCP-2 and LPL mRNA were not affected. The present results suggest that a 98 d supplementation diet with a 50 : 50 mixture of the two CLA isomers cis-9, trans-11 and trans-10, cis-12 in a dairy product was unable to alter body composition, although a significant increase in the RMR has been induced. Moreover, changes in mRNA PPAR γ and HSL in adipose tissue were recorded.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>17298695</pmid><doi>10.1017/S0007114507191911</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-9255-8228</orcidid><orcidid>https://orcid.org/0000-0003-3545-3264</orcidid><orcidid>https://orcid.org/0000-0002-9467-0317</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-1145 |
| ispartof | British journal of nutrition, 2007-02, Vol.97 (2), p.273-280 |
| issn | 0007-1145 1475-2662 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_00294435v1 |
| source | Cambridge Journals Online; Free Full-Text Journals in Chemistry |
| subjects | Acids Adipocytes Adipose tissue Adipose Tissue - physiology Adipose tissue gene expression Adult adults animal proteins basal metabolism Biological and medical sciences Biopsy Blood Glucose - analysis Body composition Body Composition - physiology Body fat Body mass index Body weight carboxylic ester hydrolases Conjugated linoleic acid Dairy products Diet Dietary Supplements domain_sdv.ida.ing domain_sdv.ida.ing.lip Double-Blind Method Energy Energy expenditure Energy metabolism Energy Metabolism - physiology enriched foods Enzymes fat free mass Fatty acids Fatty Acids - analysis Feeding. Feeding behavior Female Food engineering Fundamental and applied biological sciences. Psychology Gene expression Gene Expression - physiology Glucose Health hormone-sensitive lipase Humans Insulin - blood Ion Channels - genetics Isomers Leptin - blood Life Sciences Linoleic acid Linoleic Acids, Conjugated - administration & dosage Lipase Lipids Lipids - blood Lipoprotein lipase Lipoprotein Lipase - genetics Male Metabolism Mitochondrial Proteins - genetics Mitochondrial uncoupling protein 2 Nitrogen Nutrition Nutrition research Obesity Overweight Oxidation Peroxisome proliferator-activated receptors Plasma PPAR gamma - genetics Sterol Esterase - genetics Studies Tissues transcription factors triacylglycerols Triglycerides Uncoupling Agents Uncoupling Protein 2 Vertebrates: anatomy and physiology, studies on body, several organs or systems Yogurt |
| title | Daily intake of conjugated linoleic acid-enriched yoghurts: effects on energy metabolism and adipose tissue gene expression in healthy subjects |
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