Stability of real-time MR temperature mapping in healthy and diseased human liver

• Published in: Journal of magnetic resonance imaging 2004-04, Vol.19 (4), p.438-446
• Main Authors: Weidensteiner, Claudia, Kerioui, Noureddine, Quesson, Bruno, de Senneville, Baudoin Denis, Trillaud, Hervé, Moonen, Chrit T.W.
• Format: Article
• Language: English
• Subjects: Body Temperature; Carcinoma, Hepatocellular - physiopathology; Computer Science; Echo-Planar Imaging - methods; Humans; Image Processing, Computer-Assisted - methods; liver; Liver - physiology; Liver - physiopathology; Liver - surgery; Liver Cirrhosis - physiopathology; Liver Neoplasms - physiopathology; Liver Neoplasms - secondary; Magnetic Resonance Imaging - methods; MRI; Other; proton resonance frequency; sensitivity encoding; Signal Processing, Computer-Assisted; temperature mapping
• ISSN: 1053-1807; 1522-2586
• DOI: 10.1002/jmri.20019

Purpose To determine the stability and quality of MR temperature mapping using the proton resonance frequency (PRF) method in the liver of hepatic tumor patients. Materials and Methods The standard deviation (SD) of a series of temperature maps was determined in 30 patients (21 patients with cirrhotic livers with carcinoma, and nine patients with noncirrhotic livers with metastasis or angioma) and in five volunteers at normal body temperature under free breathing. A respiratory‐gated segmented echo‐planar imaging (EPI) sequence (three slices in one expiration phase) was performed with sensitivity encoding (SENSE) acceleration on a 1.5 T scanner. Motion‐corrupted images were identified by calculation of the cross‐correlation coefficient, and discarded. Results A T2* range of 10–33 msec was found, with especially low values in advanced cirrhotic livers. The mean temperature SD in patients was 2.3°C (range = 1.5–5.0°C). The stability in healthy livers was slightly better than that in cirrhotic livers, and it was higher in the right liver than in the left liver. The gating failed in 4% of the images when the respiratory cycle was irregular, leading to motion artifacts and errors in the temperature maps. Conclusion The achieved temperature stability and image quality makes real‐time quantitative monitoring of thermal ablation of liver tumors feasible on a clinical scanner. J. Magn. Reson. Imaging 2004;19:438–446. © 2004 Wiley‐Liss, Inc.