Dual Activation of the Drosophila Toll Pathway by Two Pattern Recognition Receptors

The Toll-dependent defense against Gram-positive bacterial infections in Drosophila is mediated through the peptidoglycan recognition protein SA (PGRP-SA). A mutation termed osiris disrupts the Gram-negative binding protein 1 (GNBP1) gene and leads to compromised survival of mutant flies after Gram-...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2003-12, Vol.302 (5653), p.2126-2130
Main Authors: Gobert, Vanessa, Gottar, Marie, Matskevich, Alexey A., Rutschmann, Sophie, Royet, Julien, Belvin, Marcia, Hoffmann, Jules A., Ferrandon, Dominique
Format: Article
Language:English
Subjects:
Amino acids
Animals
Bacteria
Biological and medical sciences
Carrier Proteins - genetics
Carrier Proteins - metabolism
Cell physiology
Cellular Biology
Coding
DNA Transposable Elements
Drosophila
Drosophila - genetics
Drosophila - immunology
Drosophila - metabolism
Drosophila - microbiology
Drosophila Proteins - genetics
Drosophila Proteins - metabolism
Fundamental and applied biological sciences. Psychology
Fungi
Gene Expression
Genes, Insect
Genetic mutation
Genetics
GNBP1 gene
Gram-Negative Bacteria - physiology
Gram-Positive Bacteria - physiology
Gram-positive bacterial infections
Hemolymph
Hemolymph - metabolism
Hypocreales - physiology
Infections
Insect Proteins - genetics
Insect Proteins - metabolism
Insects
Kinetics
Life Sciences
Logical Thinking
Microbiology
Microtubules
Molecular and cellular biology
Mutation
Pattern Recognition
Peptidoglycans
PGRP-SA protein
Phenotype
Phenotypes
Receptors, Cell Surface - genetics
Receptors, Cell Surface - metabolism
Serine Endopeptidases - genetics
Serine Endopeptidases - metabolism
Signal transduction
Toll proteins
Toll-Like Receptors
Tolls
Transposons
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Summary:The Toll-dependent defense against Gram-positive bacterial infections in Drosophila is mediated through the peptidoglycan recognition protein SA (PGRP-SA). A mutation termed osiris disrupts the Gram-negative binding protein 1 (GNBP1) gene and leads to compromised survival of mutant flies after Gram-positive infections, but not after fungal or Gram-negative bacterial challenge. Our results demonstrate that GNBP1 and PGRP-SA can jointly activate the Toll pathway. The potential for a combination of distinct proteins to mediate detection of infectious nonself in the fly will refine the concept of pattern recognition in insects.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1085432