Hypoxia signalling controls metabolic demand

It has been known for quite some time that cancer cells undergo far-reaching modifications in their metabolism, yet a full understanding of these changes and how they come about remains elusive. Even under conditions of plentiful oxygen, cancer cells choose to switch glucose metabolism from respirat...

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Bibliographic Details
Published in:Current opinion in cell biology 2007-04, Vol.19 (2), p.223-229
Main Authors: Brahimi-Horn, M Christiane, Chiche, Johanna, Pouysségur, Jacques
Format: Article
Language:English
Subjects:
Animals
Biochemistry, Molecular Biology
Cancer
Cell Hypoxia
Humans
Hydrogen-Ion Concentration
Hypoxia-Inducible Factor 1
Hypoxia-Inducible Factor 1 - metabolism
Hypoxia-Inducible Factor 1, alpha Subunit
Hypoxia-Inducible Factor 1, alpha Subunit - metabolism
Internal Medicine
Lactic Acid
Lactic Acid - metabolism
Life Sciences
Models, Biological
Neoplasms
Neoplasms - metabolism
Protein Processing, Post-Translational
Signal Transduction
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Summary:It has been known for quite some time that cancer cells undergo far-reaching modifications in their metabolism, yet a full understanding of these changes and how they come about remains elusive. Even under conditions of plentiful oxygen, cancer cells choose to switch glucose metabolism from respiration to lactic acid formation. The mystery behind the molecular mechanisms of this phenomenon, known as the Warburg effect, is now being unravelled. The reduced respiration rate and increased glucose uptake associated with lactic acid production, and acidosis of the micro-environment, are primarily due to activation of the α/β hypoxia-inducible transcription factor. This distinctive metabolic nature of cancer cells is already being exploited as a diagnostic tool but is yet to be harnessed as a therapeutic intervention.
ISSN:0955-0674
1879-0410
DOI:10.1016/j.ceb.2007.02.003