Agelasines J, K, and L from the Solomon Islands Marine Sponge Agelas cf. mauritiana

Three new diterpene alkaloids, agelasine J (3), agelasine K (4), and agelasine L (5), were isolated from the marine sponge Agelas cf. mauritiana collected in the Solomon Islands. The structures of these compounds were elucidated by physical data analyses. They displayed in vitro antimalarial activit...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2008-08, Vol.71 (8), p.1451-1454
Main Authors: Appenzeller, Jérôme, Mihci, Ghezala, Martin, Marie-Thérèse, Gallard, Jean-François, Menou, Jean-Louis, Boury-Esnault, Nicole, Hooper, John, Petek, Sylvain, Chevalley, Severine, Valentin, Alexis, Zaparucha, Anne, Al-Mourabit, Ali, Debitus, Cécile
Format: Article
Language:English
Subjects:
Agelas
agelasine
Alkaloids - chemistry
Alkaloids - isolation & purification
Alkaloids - pharmacology
Animals
anticarcinogenic activity
Antimalarials - chemistry
Antimalarials - isolation & purification
Antimalarials - pharmacology
antiprotozoal activity
Biological and medical sciences
Chemical Sciences
chemical structure
Chromatography, High Pressure Liquid
cultured cells
cytotoxicity
Diterpenes - chemistry
Diterpenes - isolation & purification
Diterpenes - pharmacology
diterpenoid alkaloids
General pharmacology
humans
Marine
Mass Spectrometry
Medical sciences
Molecular Structure
Organic chemistry
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plasmodium falciparum
Plasmodium falciparum - drug effects
Porifera
spectral analysis
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Summary:Three new diterpene alkaloids, agelasine J (3), agelasine K (4), and agelasine L (5), were isolated from the marine sponge Agelas cf. mauritiana collected in the Solomon Islands. The structures of these compounds were elucidated by physical data analyses. They displayed in vitro antimalarial activity against Plasmodium falciparum.
ISSN:0163-3864
1520-6025
DOI:10.1021/np800212g