Autoinflammatory syndromes and infections : pathogenetic and clinical implications

The autoinflammatory syndromes are a group of disorders characterized by recurrent episodes of seemingly unprovoked inflammation without significant levels of autoantobodies and antigen specific T cells. Although a direct association between defective innate immune responses to bacterial components...

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Bibliographic Details
Published in:Clinical and experimental rheumatology 2008, Vol.26 (1), p.S53-S61
Main Authors: EFTHIMIOU, P, FLAVELL, R. A, DORIA, A, FURLAN, A, GASBARRINI, G, GAVA, A, KONE-PAUT, I, MANNA, R, PUNZI, L, SUTTERWALA, F. S, TOUITOU, I
Format: Article
Language:English
Subjects:
Autoimmune Diseases - immunology
Autoimmune Diseases - microbiology
Autoimmune Diseases - virology
Biological and medical sciences
Diseases of the osteoarticular system
Errors of metabolism
Familial Mediterranean Fever - immunology
Familial Mediterranean Fever - microbiology
Familial Mediterranean Fever - virology
Genetics
Human genetics
Humans
Infection - complications
Infection - immunology
Inflammation - immunology
Inflammation - microbiology
Inflammation - virology
Inflammatory joint diseases
Life Sciences
Malformations and congenital and or hereditary diseases involving bones. Joint deformations
Medical sciences
Metabolic diseases
Miscellaneous hereditary metabolic disorders
Nod Signaling Adaptor Proteins - immunology
Still's Disease, Adult-Onset - immunology
Still's Disease, Adult-Onset - microbiology
Still's Disease, Adult-Onset - virology
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Summary:The autoinflammatory syndromes are a group of disorders characterized by recurrent episodes of seemingly unprovoked inflammation without significant levels of autoantobodies and antigen specific T cells. Although a direct association between defective innate immune responses to bacterial components and these diseases has not been formally established, much ongoing research is aimed towards confirmation of that hypothesis. This article will review recent advances in the study of a subset of NOD-like receptors (NLRs), which control the activation of caspase-1 through the assembly of a large protein complex called inflammasome. Moreover, we will review recent progresses in understanding of a range of autoinflammatory conditions in humans.
ISSN:0392-856X
1593-098X