Micro-robotics & MEMS based fabrication techniques for scaffold based tissue engineering

Scaffold based tissue engineering strategies use cells, biomolecules and a scaffold to promote the repair and regeneration of tissues. Although scaffold-based tissue engineering approaches are being actively developed, most are still experimental, and it is not yet clear what defines an ideal scaffo...

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Bibliographic Details
Published in:Macromolecular bioscience 2005-07, Vol.5 (6), p.477-489
Main Authors: Zhang, Han, Hutmacher, Dietmar, Chollet, Franck, Poo, A.N., Burdet, Etienne
Format: Article
Language:English
Subjects:
Biotechnology
Computer Science
Engineering Sciences
Life Sciences
Micro and nanotechnologies
Microelectronics
Other
Online Access:Get full text
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Summary:Scaffold based tissue engineering strategies use cells, biomolecules and a scaffold to promote the repair and regeneration of tissues. Although scaffold-based tissue engineering approaches are being actively developed, most are still experimental, and it is not yet clear what defines an ideal scaffold/cell construct. Solid free form fabrication (SFF) techniques can precisely control matrix architecture (size, shape, interconnectivity, branching, geometry and orientation). The SFF methods enable the fabrication of scaffolds with various designs and material compositions, thus providing a control of mechanical properties, biological effects and degradation kinetics. This paper reviews the application of micro-robotics and MEMS-based fabrication techniques for scaffold design and fabrication. It also presents a novel robotic technique to fabricate scaffold/cell constructs for tissue engineering by the assembly of microscopic building blocks.
ISSN:1616-5187
1616-5195