Overexpression of the Angiogenic Tetrapeptide AcSDKP in Human Malignant Tumors

Background: The natural tetrapeptide acetyl-Ser-Asp-Lys-Pro (AcSDKP), generated from thymosin β4 following its cleavage by prolyl oligopeptidase (POP), is a physiological stimulator of angiogenesis. Because of the critical role of neovascularisation in tumor development, the expression of AcSDKP an...

Full description

Saved in:
Bibliographic Details
Published in:Anticancer research 2008-09, Vol.28 (5A), p.2813-2817
Main Authors: LIU, Jian-Miao, KUSINSKI, Michal, ILIC, Vesna, BIGNON, Jérome, HAJEM, Neila, KOMOROWSKI, Jan, KUZDAK, Krzysztof, STEPIEN, Henryk, WDZIECZAK-BAKALA, Joanna
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Biological and medical sciences
Carcinoma, Papillary - blood
Carcinoma, Papillary - enzymology
Carcinoma, Papillary - metabolism
Chemical Sciences
Female
Humans
Male
Medical sciences
Middle Aged
Neoplasms - blood
Neoplasms - enzymology
Neoplasms - metabolism
Oligopeptides - biosynthesis
Oligopeptides - blood
Organic chemistry
Serine Endopeptidases - metabolism
Thyroid Neoplasms - blood
Thyroid Neoplasms - enzymology
Thyroid Neoplasms - metabolism
Tumors
Young Adult
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: The natural tetrapeptide acetyl-Ser-Asp-Lys-Pro (AcSDKP), generated from thymosin β4 following its cleavage by prolyl oligopeptidase (POP), is a physiological stimulator of angiogenesis. Because of the critical role of neovascularisation in tumor development, the expression of AcSDKP and the activity of POP were examined in different human solid malignancies. Materials and Methods: The expression of AcSDKP and the activity of POP were evaluated in human blood samples and tissue specimens of thyroid goiter and thyroid papillary carcinoma as well as in commercial cancer tissue microarray. Results: A significantly increased concentration of AcSDKP in intratumoral blood and enhanced tissular activity of POP were detected in cancer patients. The expression of AcSDKP in human breast, colon, head and neck, kidney, lung, skin, ovary and prostate cancer tissues was shown to be greater than that in normal tissues. Conclusion: AcSDKP and POP contribute to the malignant phenotype and these molecules are potentiel markers of cancer.
ISSN:0250-7005
1791-7530