Self-Diffusion in Chitosan Networks: From a Gel−Gel Method to Fluorescence Recovery after Photobleaching by Fringe Pattern

The diffusion properties of caffeine and dextran within chitosan networks with controlled structure were investigated using a gel−gel method and fluorescence recovery after photobleaching (FRAP) by fringe pattern. The center of mass diffusion was studied by varying the molecular weight of dextran ma...

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Bibliographic Details
Published in:Macromolecules 2008-12, Vol.41 (23), p.9376-9381
Main Authors: Payet, Linda, Ponton, Alain, Léger, Liliane, Hervet, Hubert, Grossiord, J. Louis, Agnely, Florence
Format: Article
Language:English
Subjects:
Applied sciences
Biological and medical sciences
Biomechanics
Engineering Sciences
Exact sciences and technology
General pharmacology
Mechanics
Medical sciences
Natural polymers
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Physicochemistry of polymers
Physics
Starch and polysaccharides
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Summary:The diffusion properties of caffeine and dextran within chitosan networks with controlled structure were investigated using a gel−gel method and fluorescence recovery after photobleaching (FRAP) by fringe pattern. The center of mass diffusion was studied by varying the molecular weight of dextran macromolecules labeled with fluorescein isothiocyanate (FITC). It was shown that the diffusion was drastically slowed down above a critical molecular weight around 105 g/mol.
ISSN:0024-9297
1520-5835
DOI:10.1021/ma801192q