Glycosylated asterisks are among the most potent low valency inducers of Concanavalin A aggregation

A new class of sulfurated, semi-rigid, radial and low-valent glycosylated asterisk ligands with potential dual function as ligand and probe has some of the highest inhibition potencies of Con A-induced hemagglutination, by using a cross-linking mechanism of Con A which amplifies the enhancement to n...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2008-01 (48), p.6507-6509
Main Authors: Sleiman, Mazen, Varrot, Annabelle, Raimundo, Jean-Manuel, Gingras, Marc, Goekjian, Peter G
Format: Article
Language:English
Subjects:
Animals
Concanavalin A - chemistry
Glycosylation
Hemagglutination Tests
Rabbits
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Summary:A new class of sulfurated, semi-rigid, radial and low-valent glycosylated asterisk ligands with potential dual function as ligand and probe has some of the highest inhibition potencies of Con A-induced hemagglutination, by using a cross-linking mechanism of Con A which amplifies the enhancement to near nanomolar concentrations with the alpha-d-mannose asterisk.
ISSN:1359-7345
1364-548X
DOI:10.1039/b814816c