Antibacterial activity of glycine betaine analogues: involvement of osmoporters

Glycine betaine (GB) analogues were obtained using solid phase organic synthesis and assayed for their toxic activity against 15 Gram positive and Gram negative bacteria. Four benzyl derivatives of GB were selected to determine their effect on bacterial growth. Bacteriostatic and lethal effects were...

Full description

Saved in:
Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2004-05, Vol.14 (9), p.2061-2065
Main Authors: COSQUER, Anne, FICAMOS, Morgane, JEBBAR, Mohamed, CORBEL, Jean-Charles, CHOQUET, Gwénaëlle, FONTENELLE, Catherine, URIAC, Philippe, BERNARD, Théophile
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Betaine
Betaine - chemistry
Betaine - pharmacology
Biological and medical sciences
Biological Transport
Gram-Negative Bacteria
Gram-Negative Bacteria - drug effects
Gram-Negative Bacteria - growth & development
Gram-Positive Bacteria
Gram-Positive Bacteria - drug effects
Gram-Positive Bacteria - growth & development
Life Sciences
Medical sciences
Microbial Sensitivity Tests
Microbiology and Parasitology
Osmosis
Pharmacology. Drug treatments
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Glycine betaine (GB) analogues were obtained using solid phase organic synthesis and assayed for their toxic activity against 15 Gram positive and Gram negative bacteria. Four benzyl derivatives of GB were selected to determine their effect on bacterial growth. Bacteriostatic and lethal effects were observed for compound 1 and compound 2, respectively. The importation of the two GB analogues into bacterial cells appeared strictly dependent on the presence of the powerful betaine membrane osmoporters; their capacity to be amassed intracellularly at molar levels from extremely dilute solutions might constitute a basis to design a new class of antimicrobial agents.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2004.02.045