Human adipose cells as candidates in defense and tissue remodeling phenomena

Macrophages are part of the immunity defense mechanism via oxidative burst and phagocytosis. They are also involved in tissue remodeling via cytokine secretion and apoptotic body clearance. Previously, we demonstrated that adipose cells and macrophages share some of their features and functions. Our...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2003-09, Vol.309 (3), p.502-505
Main Authors: Saillan-Barreau, C, Cousin, B, André, M, Villena, P, Casteilla, L, Pénicaud, L
Format: Article
Language:English
Subjects:
Adipocytes - cytology
Adipocytes - physiology
Adipose Tissue - cytology
Apoptosis
Cells, Cultured
Female
Food and Nutrition
Human
Humans
Immunity
Jurkat Cells
Life Sciences
Macrophage
Male
Middle Aged
Phagocytosis
Plasticity
Preadipocyte
Stem Cells - physiology
Tissue remodeling
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Summary:Macrophages are part of the immunity defense mechanism via oxidative burst and phagocytosis. They are also involved in tissue remodeling via cytokine secretion and apoptotic body clearance. Previously, we demonstrated that adipose cells and macrophages share some of their features and functions. Our aim was to further test this hypothesis in humans. We first demonstrated that human preadipocytes exhibit phagocytosis of yeast, this effect being specific compared to another fibroblastic cell type, the skin fibroblast. Furthermore, as in rodents, human preadipocytes exhibit anti-microbial activity. Finally, for the first time, it was shown that these cells were able to phagocyte apoptotic lymphocytes. Altogether, these data suggest an active involvement of fat cells in host defense and tissue remodeling, which might play an important role at the level of the whole organism due to the large amount of adipose tissue. This gives support for some observations linking obesity or cachexia to immunological disorders.
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2003.08.034