Cardioprotective effect of chronic low dose ethanol drinking: Insights into the concept of ethanol preconditioning

The reason why low-to-moderate alcohol drinking is associated with reduced cardiovascular mortality is not elucidated. While data suggested that ethanol drinking may have a protective effect on global cardiac ischemia, the effect of chronic low dose ethanol drinking (CLEthD) on myocardial infarct si...

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Bibliographic Details
Published in:Journal of molecular and cellular cardiology 2004-04, Vol.36 (4), p.561-566
Main Authors: Guiraud, Annabelle, de Lorgeril, Michel, Boucher, François, Berthonneche, Corinne, Rakotovao, Andry, de Leiris, Joël
Format: Article
Language:English
Subjects:
Alcohol
Alcohol Drinking
Animals
Cardiology and cardiovascular system
Central Nervous System Depressants
Central Nervous System Depressants - pharmacology
Coronary heart disease
Ethanol
Ethanol - pharmacology
Heart
Heart - drug effects
Human health and pathology
Humans
Ischemic preconditioning
Ischemic Preconditioning, Myocardial
Left ventricular function
Life Sciences
Myocardial Infarction
Myocardial Infarction - pathology
Myocardial Ischemia
Myocardium
Myocardium - pathology
Perfusion
Protein Isoforms
Protein Kinase C
Protein Kinase C - chemistry
Protein Kinase C - metabolism
Rats
Reperfusion Injury
Risk Factors
Time Factors
Ventricular Function, Left
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Summary:The reason why low-to-moderate alcohol drinking is associated with reduced cardiovascular mortality is not elucidated. While data suggested that ethanol drinking may have a protective effect on global cardiac ischemia, the effect of chronic low dose ethanol drinking (CLEthD) on myocardial infarct size has not been evaluated in a model of regional ischemia. Using an isolated rat heart model to exclude the effect of various in vivo confounders, we have studied the effect of CLEthD on infarct size (IS) and left ventricular function after 30 min of regional ischemia and 120 min of reperfusion. The effect of CLEthD was compared with ischemic preconditioning (IPC) and protein kinase C (PKC) isoforms were analysed in the myocardium before the 30-min ischemia. Ethanol-fed rats received 9% (v/v) ethanol in their drinking water for 7 weeks. Four groups of rats were studied: (1) control, (2) ethanol, (3) control + IPC, (4) ethanol + IPC. Compared with controls (59 ± 10), IS (as percent of risk zone) was smaller in the ethanol (39 ± 6) and IPC (31 ± 8) groups (both p 
ISSN:0022-2828
1095-8584
DOI:10.1016/j.yjmcc.2004.02.003