How to Improve Chemical Synthesis of Laminaribiose on a Large Scale

Laminaribiose, which is the simplest beta -(1,3)-glucan, is one of the most powerful agents able to increase germination. Its chemical synthesis was revised in detail starting from peracylated donors and easily available glucofuranose protected by acetal groups in the presence of appropriated cataly...

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Bibliographic Details
Published in:Open glycoscience 2008-06, Vol.1 (1), p.19-24
Main Authors: Jamois, F., Goffic, F. Le, Yvin, J. C., Plusquellec, D., Ferrieres, V.
Format: Article
Language:English
Subjects:
Chemical Sciences
Organic chemistry
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Summary:Laminaribiose, which is the simplest beta -(1,3)-glucan, is one of the most powerful agents able to increase germination. Its chemical synthesis was revised in detail starting from peracylated donors and easily available glucofuranose protected by acetal groups in the presence of appropriated catalyst and/or promoter. We particularly focused our attention on the nature of the Lewis acid generally required in glycosidic couplings. Finally, an interesting scale-up was performed which allowed us to prepare laminaribiose on a kilogram scale.
ISSN:1875-3981
1875-3981
DOI:10.2174/1875398100801010019