Improvement in colorectal cancer survival: A population-based study

The aim of this study was to explore the reasons for improvement in colorectal cancer survival. Trends in relative survival among 5874 patients diagnosed with colorectal cancer over a 24-year period in a well-defined French population were analysed. The 5-year relative survival rate, excluding opera...

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Bibliographic Details
Published in:European journal of cancer (1990) 2005-10, Vol.41 (15), p.2297-2303
Main Authors: Mitry, Emmanuel, Bouvier, Anne-Marie, Esteve, Jacques, Faivre, Jean
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Chemotherapy, Adjuvant
Colorectal neoplasms
Colorectal Neoplasms - drug therapy
Colorectal Neoplasms - mortality
Colorectal Neoplasms - surgery
Epidemiology
Female
France - epidemiology
Humans
Life Sciences
Lymphatic Metastasis
Male
Medical sciences
Mortality - trends
Multivariate Analysis
Other
Pharmacology. Drug treatments
Prognosis
Registries
Survival
Survival Analysis
Survival Rate
Time Factors
Tumors
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Summary:The aim of this study was to explore the reasons for improvement in colorectal cancer survival. Trends in relative survival among 5874 patients diagnosed with colorectal cancer over a 24-year period in a well-defined French population were analysed. The 5-year relative survival rate, excluding operative mortality, increased from 49.2% to 56.3% between the periods 1976–1987 and 1988–1999. In multivariate analysis, stage at diagnosis and adjuvant chemotherapy were both associated with better survival after surgery with curative intent. Survival trends differed markedly by age. The improvement in overall survival for older patients can be attributed to the increase in the proportion of patients resected for cure. For younger patients, there was an increase in the proportion of patients operated for cure, but also an improvement in stage-specific survival, particularly for stage III tumours, suggesting an impact of adjuvant chemotherapy.
ISSN:0959-8049
1879-0852
DOI:10.1016/j.ejca.2005.01.028