A convenient synthesis of novel spiroisoindolone g-halobutyrolactones via halocyclization of g-ethylenic acids

γ-Ethylenic carboxylic acids are cyclized to spiroisoindolone γ-halomethylbutyrolactones, in the presence of NBS or NIS and K2CO3. The corresponding haloaspirobutyrolactones were isolated in high yields (57-95%).

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Bibliographic Details
Published in:Heterocycles 2009, Vol.78 (11), p.2787-2798
Main Authors: Rammah, M. M., Othman, M., Ciamala, K., Knorr, M., Strohmann, C.
Format: Article
Language:English
Subjects:
Chemical Sciences
Online Access:Get full text
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Description
Summary:γ-Ethylenic carboxylic acids are cyclized to spiroisoindolone γ-halomethylbutyrolactones, in the presence of NBS or NIS and K2CO3. The corresponding haloaspirobutyrolactones were isolated in high yields (57-95%).
ISSN:0385-5414
1881-0942
DOI:10.3987/COM-09-11787