Model predictive control during the primary drying stage of lyophilisation

During the primary drying stage of pharmaceutical solutions in vial, the sublimation front is the boundary between the dried and frozen layers that moves from the top of the vial to its bottom. While only few on-line measures are available, it is an important variable to control. This paper deals wi...

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Bibliographic Details
Published in:Control engineering practice 2010-05, Vol.18 (5), p.483-494
Main Authors: Daraoui, N., Dufour, P., Hammouri, H., Hottot, A.
Format: Article
Language:English
Subjects:
Applied sciences
Automatic
Biological and medical sciences
Boundaries
Chemical engineering
Computer programs
Computer science
control theory
systems
Control theory. Systems
Drying
Engineering Sciences
Exact sciences and technology
General pharmacology
Heat and mass transfers
Lyophilisation
Mathematical models
Medical sciences
Model predictive control
On-line systems
Optimal control
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Predictive control
Process control
Process control. Computer integrated manufacturing
Sublimation
Vials
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Summary:During the primary drying stage of pharmaceutical solutions in vial, the sublimation front is the boundary between the dried and frozen layers that moves from the top of the vial to its bottom. While only few on-line measures are available, it is an important variable to control. This paper deals with the on-line partial differential equation model-based predictive control of the sublimation front position, assuming two strategies based on various availability of measurement used in the feedback loop. Through the MPC@CB control software, the robustness of the controller with respect to the main model parameter uncertainty is shown.
ISSN:0967-0661
1873-6939
DOI:10.1016/j.conengprac.2010.01.005