Effects of anti-depressants on olfactory sensitivity in mice

Some studies have underlined a decrease in olfactory sensitivity in patients suffering from depression. The present study aims to evaluate the effects of current anti-depressant drugs on the olfactory sensitivity in mice. (N° = 22) were tested in a Y-maze with a choice between an odorant (butanol) o...

Full description

Saved in:
Bibliographic Details
Published in:Progress in neuro-psychopharmacology & biological psychiatry 2008-04, Vol.32 (3), p.629-632
Main Authors: Lombion, Sandrine, Morand-Villeneuve, Nadège, Millot, Jean-Louis
Format: Article
Language:English
Subjects:
Analysis of Variance
Animals
Antidepressive Agents
Antidepressive Agents - pharmacology
Behavior, Animal
Behavior, Animal - drug effects
Biological and medical sciences
Choice Behavior
Choice Behavior - drug effects
Citalopram
Citalopram - pharmacology
Clomipramine
Clomipramine - pharmacology
Discrimination (Psychology)
Discrimination (Psychology) - drug effects
Female
Life Sciences
Maze Learning
Maze Learning - drug effects
Medical sciences
Mice
Neurons and Cognition
Neuropharmacology
Odorants
Odors
Olfactory Pathways
Olfactory Pathways - drug effects
Olfactory sensitivity
Pharmacology. Drug treatments
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Side effects
Time Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Some studies have underlined a decrease in olfactory sensitivity in patients suffering from depression. The present study aims to evaluate the effects of current anti-depressant drugs on the olfactory sensitivity in mice. (N° = 22) were tested in a Y-maze with a choice between an odorant (butanol) or distilled water before and during 3 weeks of daily intra-peritoneal injection of either citalopram or clomipramine. Their performance was compared with those of a control group (N° = 11) injected with a saline solution. The results showed a significant decrease in olfactory sensitivity with both anti-depressants during the three weeks of treatment. The antidepressant induced alteration in serotonin and/or noradrenaline transmission in the olfactory bulb may account for the altered olfactory sensitivity observed in this study.
ISSN:0278-5846
1878-4216
DOI:10.1016/j.pnpbp.2007.10.021