AUC/MIC: a PK/PD index for antibiotics with a time dimension or simply a dimensionless scoring factor?

A previous article on standardization of pharmacokinetic/pharmacodynamic terminology for anti-infective drugs recommended deletion of the units of the AUC/MIC ratio (actually h). We express here the difficulties presented by this proposal and we propose expressing AUC/MIC as a scaling factor corresp...

Full description

Saved in:
Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 2007-12, Vol.60 (6), p.1185-1188
Main Authors: Toutain, Pierre-Louis, Bousquet-Mélou, Alain, Martinez, Marilyn
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - pharmacokinetics
Anti-Bacterial Agents - therapeutic use
Antibiotics. Antiinfectious agents. Antiparasitic agents
Area Under Curve
Biological and medical sciences
Biomedical research
Cattle
Drug dosages
Humans
Life Sciences
Measurement techniques
Medical sciences
Microbial Sensitivity Tests
Microbial Sensitivity Tests - standards
Microbiology
Models, Biological
Oxytetracycline
Oxytetracycline - administration & dosage
Oxytetracycline - pharmacokinetics
Oxytetracycline - therapeutic use
Pharmaceutical sciences
Pharmacology
Pharmacology. Drug treatments
PK/PD index
Ratios
standardization
Terminology
Terminology as Topic
time dimension
Time Factors
Veterinary services
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A previous article on standardization of pharmacokinetic/pharmacodynamic terminology for anti-infective drugs recommended deletion of the units of the AUC/MIC ratio (actually h). We express here the difficulties presented by this proposal and we propose expressing AUC/MIC as a scaling factor corresponding to the current index divided now by 24 h. This is the scaling factor without units by which the targeted MIC should be multiplied to estimate the average in vivo plasma concentration to be achieved. Associated with this proposal, we address the specific issue of veterinary drug products for which steady conditions are seldom achieved. To accommodate the need for dose prediction during these novel therapeutic situations, we propose a general approach that is based on the targeted time interval over which some desired average concentration should be maintained.
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/dkm360