Bioactive Phenylpropanoids from Daucus crinitus Desf. from Algeria

The volatile constituents of Daucus crinitus Desf. from Algeria were analyzed by GC and GC-MS, The main constituent was isochavicol isobutyrate (39.0%), an uncommon phenylpropanoid. By synthesis of a series of homologous esters, it was also possible to determine the presence of small amounts of isoc...

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Bibliographic Details
Published in:Journal of agricultural and food chemistry 2010-02, Vol.58 (4), p.2174-2179
Main Authors: Lanfranchi, Don-Antoine, Laouer, Hocine, El Kolli, Meriem, Prado, Soizic, Maulay-Bailly, Christine, Baldovini, Nicolas
Format: Article
Language:English
Subjects:
Algeria
Analytical chemistry
Animals
Anti-Infective Agents - isolation & purification
Anti-Infective Agents - pharmacology
Antifungal Agents - isolation & purification
Antifungal Agents - pharmacology
Antiprotozoal Agents - isolation & purification
Antiprotozoal Agents - pharmacology
Apiaceae - chemistry
Aspergillus niger - drug effects
Bacteria - drug effects
Bioactive Constituents
bioactive properties
Biological and medical sciences
Candida albicans - drug effects
chemical analysis
chemical composition
Chemical Sciences
Daucus
Daucus crinitus
DNA Damage - drug effects
essential oils
Esters - isolation & purification
Esters - pharmacology
Food industries
Food microbiology
Fundamental and applied biological sciences. Psychology
Gas Chromatography-Mass Spectrometry
medicinal plants
Oils, Volatile - isolation & purification
Oils, Volatile - pharmacology
phytogeography
Plasmodium falciparum - drug effects
volatile compounds
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Summary:The volatile constituents of Daucus crinitus Desf. from Algeria were analyzed by GC and GC-MS, The main constituent was isochavicol isobutyrate (39.0%), an uncommon phenylpropanoid. By synthesis of a series of homologous esters, it was also possible to determine the presence of small amounts of isochavicol propionate, which has never been described previously as a natural product. The antibacterial and antifungal activities of the whole essential oil, of these two esters, and of isochavicol itself were investigated against a wide range of bacteria and fungi. Additionally, their antimalarial and antiradical properties were also evaluated, showing an interesting antiplasmodial activity of isochavicol.
ISSN:0021-8561
1520-5118
DOI:10.1021/jf903760b