Genetic characterization of G3 rotaviruses detected in Italian children in the years 1993-2005

In recent years an apparent increase in the frequency of detection of G3P[8] rotaviruses has been observed worldwide. Similarly, in Italy G3P[8] strains have been detected sporadically and in a scattered fashion over 20 years, whereas in 2003 and 2005 G3P[8] rotavirus activity increased markedly. By...

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Bibliographic Details
Published in:Journal of medical virology 2009-12, Vol.81 (12), p.2089-2095
Main Authors: De Grazia, Simona, Martella, Vito, Colomba, Claudia, Cascio, Antonio, Arista, Serenella, Giammanco, Giovanni M
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Antigens, Viral - analysis
Antigens, Viral - genetics
Biological and medical sciences
Capsid Proteins - analysis
Capsid Proteins - genetics
Child, Preschool
Feces - virology
Fundamental and applied biological sciences. Psychology
gastroenteritis
Genetics
Glycoproteins - analysis
Glycoproteins - genetics
Human viral diseases
Humans
Infant
Infant, Newborn
Infectious diseases
Italy
Italy - epidemiology
Medical sciences
Microbiology
Miscellaneous
Molecular Sequence Data
NSP4
Phylogeny
RNA, Viral - genetics
RNA, Viral - isolation & purification
Rotavirus - genetics
rotavirus G3P
Rotavirus Infections - epidemiology
Rotavirus Infections - virology
sequence analysis
Sequence Analysis, RNA
Toxins, Biological - analysis
Toxins, Biological - genetics
Viral diseases
Viral Nonstructural Proteins - analysis
Viral Nonstructural Proteins - genetics
Virology
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Description
Summary:In recent years an apparent increase in the frequency of detection of G3P[8] rotaviruses has been observed worldwide. Similarly, in Italy G3P[8] strains have been detected sporadically and in a scattered fashion over 20 years, whereas in 2003 and 2005 G3P[8] rotavirus activity increased markedly. By analysis of the VP7, VP4, VP6, and NSP4 genes of a selection of G3P[8] rotaviruses detected between 1993 and 2005, a remarkable sequence conservation was observed in the VP7, VP4, and VP6 genes. By converse, after 2002 the Italian G3P[8] strains were found to possess unique mutations in significant regions of the NSP4 protein. J. Med. Virol. 81:2089-2095, 2009.
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.21615