TRPML and lysosomal function

Mucolipin 1 (MLN1), also known as TRPML1, is a member of the mucolipin family. The mucolipins are the only lysosomal proteins within the TRP superfamily. Mutations in the gene coding for TRPML1 result in a lysosomal storage disorder (LSD). This review summarizes the current knowledge related to this...

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Bibliographic Details
Published in:Biochimica et biophysica acta 2007-08, Vol.1772 (8), p.851-858
Main Authors: Zeevi, David A., Frumkin, Ayala, Bach, Gideon
Format: Article
Language:English
Subjects:
Animals
Endocytosis and lysosomal function
Humans
Lysosomal storage disorder
Lysosomes - genetics
Lysosomes - metabolism
Lysosomes - physiology
Models, Biological
Mucolipidosis
Mucolipin protein family
Protein Binding
Protein Transport
Transient Receptor Potential Channels - genetics
Transient Receptor Potential Channels - metabolism
Transient Receptor Potential Channels - physiology
TRPM Cation Channels - genetics
TRPM Cation Channels - metabolism
TRPM Cation Channels - physiology
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Description
Summary:Mucolipin 1 (MLN1), also known as TRPML1, is a member of the mucolipin family. The mucolipins are the only lysosomal proteins within the TRP superfamily. Mutations in the gene coding for TRPML1 result in a lysosomal storage disorder (LSD). This review summarizes the current knowledge related to this protein and the rest of the mucolipin family.
ISSN:0925-4439
0006-3002
1879-260X
DOI:10.1016/j.bbadis.2007.01.004