Clara cell protein in full-term pregnancies: The influence of intrauterine growth restriction

Background Clara cell protein (CC16) is an immunomodulatory/anti‐inflammatory broncho‐alveolar‐derived molecule and a biomarker of pulmonary epithelial cells maturity and alveolo‐capillary membrane injury. Intrauterine growth‐restricted (IUGR) neonates may present with structural lung immaturity, im...

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Published in:Pediatric pulmonology 2010-12, Vol.45 (12), p.1186-1191
Main Authors: Briana, Despina D., Gourgiotis, Dimitrios, Boutsikou, Maria, Baka, Stavroula, Marmarinos, Antonios, Liosi, Sofia, Hassiakos, Dimitrios, Malamitsi-Puchner, Ariadne
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Clara cell protein
Female
Fetal Growth Retardation - blood
fetus
General aspects
Gestational Age
Humans
Infant, Newborn - blood
intrauterine growth restriction
lung
Male
Medical sciences
neonate
Pneumology
Postpartum Period
Pregnancy - blood
Uteroglobin - blood
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Summary:Background Clara cell protein (CC16) is an immunomodulatory/anti‐inflammatory broncho‐alveolar‐derived molecule and a biomarker of pulmonary epithelial cells maturity and alveolo‐capillary membrane injury. Intrauterine growth‐restricted (IUGR) neonates may present with structural lung immaturity, impaired immunocompetence and increased risk for respiratory infections and chronic obstructive lung disease in later life. Objectives To investigate circulating CC16 concentrations in maternal, fetal, and neonatal samples from IUGR and appropriate for gestational age (AGA) pregnancies. Methods Serum CC16 concentrations were determined by EIA in 40 mothers and their 20 IUGR and 20 AGA singleton full‐term fetuses–neonates on postnatal days 1 (N1) and 4 (N4). Results No significant differences in CC16 concentrations were observed between IUGR and AGA groups. In both groups, maternal CC16 concentrations were lower compared to N1 and N4 ones (P 
ISSN:8755-6863
1099-0496
DOI:10.1002/ppul.21305