Doxorubicin Loaded Magnetic Polymersomes: Theranostic Nanocarriers for MR Imaging and Magneto-Chemotherapy

• Published in: ACS nano 2011-02, Vol.5 (2), p.1122-1140
• Main Authors: Sanson, Charles, Diou, Odile, Thévenot, Julie, Ibarboure, Emmanuel, Soum, Alain, Brûlet, Annie, Miraux, Sylvain, Thiaudière, Eric, Tan, Sisareuth, Brisson, Alain, Dupuis, Vincent, Sandre, Olivier, Lecommandoux, Sébastien
• Format: Article
• Language: English
• Subjects: Antineoplastic Agents - chemistry; Antineoplastic Agents - metabolism; Antineoplastic Agents - therapeutic use; Biocompatible Materials - chemistry; Chemical Precipitation; Chemical Sciences; Contrast Media; Dioxanes - chemistry; Doxorubicin - chemistry; Doxorubicin - metabolism; Doxorubicin - therapeutic use; Drug Carriers - chemistry; Ferric Compounds - chemistry; Humans; Hydrophobic and Hydrophilic Interactions; Hyperthermia, Induced; Magnetic Field Therapy - methods; Magnetic Resonance Imaging - methods; Magnetics; Material chemistry; Medicinal Chemistry; Membranes, Artificial; Motion; Nanostructures - chemistry; Polyglutamic Acid - chemistry; Polymers - chemistry
• ISSN: 1936-0851; 1936-086X
• DOI: 10.1021/nn102762f

Hydrophobically modified maghemite (γ-Fe2O3) nanoparticles were encapsulated within the membrane of poly(trimethylene carbonate)-b-poly(l-glutamic acid) (PTMC-b-PGA) block copolymer vesicles using a nanoprecipitation process. This formation method gives simple access to highly magnetic nanoparticles (MNPs) (loaded up to 70 wt %) together with good control over the vesicles size (100−400 nm). The simultaneous loading of maghemite nanoparticles and doxorubicin was also achieved by nanoprecipitation. The deformation of the vesicle membrane under an applied magnetic field has been evidenced by small angle neutron scattering. These superparamagnetic hybrid self-assemblies display enhanced contrast properties that open potential applications for magnetic resonance imaging. They can also be guided in a magnetic field gradient. The feasibility of controlled drug release by radio frequency magnetic hyperthermia was demonstrated in the case of encapsulated doxorubicin molecules, showing the viability of the concept of magneto-chemotherapy. These magnetic polymersomes can be used as efficient multifunctional nanocarriers for combined therapy and imaging.